Research Scientist, Medicinal Chemistry
3 weeks ago
Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating BT8009, a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA.
Culture is key and all Bicycle employees actively embrace and role model our company values:
- We are Adventurous. We believe it's the way to deliver extraordinary results for our patients.
- We are Dedicated to our Mission. You can't change the world if you don't have determination
- We are One Team. We only succeed when we work together.
We have a new opportunity for a Research Scientist who will join a dynamic and fast-moving team and will be primarily responsible for the design and synthesis of novel Bicycles and conjugates with a goal of developing lead candidates. In this role you will be required to manage external resources to deliver on synthetic and analytical tasks and will also work collaboratively with the scientific team in a project team environment to progress Bicycle’s oncology pipeline.
You will have demonstrated a good level of proficiency in modern synthetic organic / medicinal chemistry as applied to drug discovery and lead optimization of small molecules and peptides and will have experience in the application of structure based design, the use of non-natural amino acids, linkers and conjugation chemistries. You will work as part of the Medicinal Chemistry team and will contribute to the chemical optimisation of Bicycle monomers and the design and synthesis of Bicycle oncology agents via external CRO partners. For project centric activities, data and progress review, the role will involve close interaction with the Platform, Biology, DMPK and in vivo Pharmacology teams.
Key responsibilities:
- Supporting chemistry activities within a project team, including the design of bioactive Bicycle® peptides to a set Target Product Profile
- Serve on internal project teams, communicate with project team and colleagues effectively and work well with others to meet experimental and organizational goals.
- Present the results of research activities effectively in oral or written form to line manager, project team members and management level meetings.
- Coordinate chemistry at external contract research organizations (CROs) including maintaining a good relationship, development of chemistry plans, project tracking, data and compound management, evaluation of results and analytical data including NMR, LCMS, HPLC, UV-VIS and troubleshooting synthetic issues.
- Prepare reports and contribute to drafting patent filings and journal manuscripts
- Supporting the development of new innovations which expand the company platform
Essential:
- Relevant industry or academic experience in contemporary medicinal chemistry and in the design and synthesis of bioactive peptides and conjugates in preclinical drug discovery programs
- Experience in interpreting SAR data desirable (activity, selectivity, DMPK characteristics, physical properties etc.)
- Demonstrated experience in managing external (CRO, CMO) resources to accomplish project tasks
- Excellent organizational skills and ability to work independently, flexibly and reliably, prioritizing accordingly to the company objectives
- Team player who collaborates and communicates effectively in team environment. Comfortable sharing knowledge with wider company team and, as appropriate, report work to the scientific or industry community
- Innovative, entrepreneurial, enjoys working in a fast-paced environment
Desirable:
- Experience in peptide chemistry research while not essential is highly desirable
- Experience in developing drug conjugates or radiopharmaceuticals
- Use of structure based drug design and the use of computational modelling and data analysis software to support drug development activities
- State-of-the-art campus environment with on campus restaurant and Montessori nursery
- Flexible working environment
- Competitive reward including annual company bonus
- Employee recognition schemes
- 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
- Employer contribution to pension (employee does not have to contribute)
- Life assurance cover 4x basic salary
- Private Medical Insurance, including optical and dental cover.
- Group income protection
- Employee assistance program
- Health Cash Plan
- Access to company subsidized gym membership.
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
- Cycle to work scheme
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
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Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full timeJob SummaryWe are seeking a highly skilled Research Scientist to join our dynamic Medicinal Chemistry team at Bicycle Therapeutics. As a key member of our team, you will be responsible for designing and synthesizing novel Bicycles and conjugates to develop lead candidates for our oncology pipeline.Key ResponsibilitiesDesign and synthesis of novel Bicycles...
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