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Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full timeJob DescriptionWe are seeking a highly skilled Research Scientist to join our dynamic and fast-paced Medicinal Chemistry team at Bicycle Therapeutics. As a key member of our team, you will be responsible for the design and synthesis of novel bioactive peptides and conjugates, with a focus on developing lead candidates for our oncology pipeline.Key...
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Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full timeJob DescriptionWe are seeking a highly skilled Research Scientist to join our dynamic and fast-paced Medicinal Chemistry team at Bicycle Therapeutics. As a key member of our team, you will be responsible for the design and synthesis of novel bioactive peptides and conjugates, with a focus on developing lead candidates for our oncology pipeline.Key...
Principal Scientist, Medicinal Chemistry
2 months ago
Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating BT8009, a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA.
Culture is key and all Bicycle employees actively embrace and role model our company values:
- We are Adventurous. We believe it's the way to deliver extraordinary results for our patients.
- We are Dedicated to our Mission. You can't change the world if you don't have determination
- We are One Team. We only succeed when we work together.
We have a new opportunity for a Principle Scientist who will join a dynamic and fast-moving team and will be primarily responsible for the design and synthesis of novel Bicycles and conjugates with a goal of delivering clinical candidates. In this role you will be required to manage external resources to deliver on synthetic and analytical tasks and will also work collaboratively with the scientific team in a project team environment to progress Bicycle’s oncology pipeline.
You will have demonstrated a high level of proficiency in modern synthetic organic / medicinal chemistry as applied to drug discovery and lead optimization of small molecules and peptides and will be experienced in the application of structure based design, the use of non-natural amino acids, linkers and novel conjugation chemistries. You will work as part of the Medicinal Chemistry team and will contribute to the chemical optimisation of Bicycle monomers and the design and synthesis of Bicycle oncology agents via external CRO partners. For project centric activities, data and progress review, the role will involve close interaction with the Platform, Biology, DMPK, in vivo Pharmacology, Translational Sciences and CMC teams.
Key responsibilities:
- Driving chemistry activities within a project team, including the design of bioactive Bicycle® peptides to a set Target Product Profile
- Serve on internal project teams, communicate with project team and colleagues effectively and work well with others to meet experimental and organizational goals.
- Present the results of independently conducted research effectively in oral or written form to line manager, project team members and management level meetings.
- Manage chemistry at external contract research organizations (CROs) including maintaining a good relationship, development of detailed chemistry plans, project tracking, data and compound management, critical evaluation of results and analytical data including NMR, LCMS, HPLC, UV-VIS and troubleshooting synthetic issues.
- Prepare reports and contribute to drafting and reviewing patent filings.
- Prepare manuscripts for submission to peer reviewed journals
- Introducing and developing new innovations which expand the company platform
- Relevant industry or academic experience in contemporary medicinal/peptide chemistry and in the design and synthesis of bioactive peptides and conjugates in preclinical drug discovery programs
- Experience in structure based drug design and the use of computational modelling and data analysis software to interpret SAR data (activity, selectivity, DMPK characteristics, physical properties etc.)
- Experience in developing drug conjugates or radiopharmaceuticals is highly desirable
- Demonstrated experience in managing external (CRO, CMO) resources to accomplish project tasks
- Excellent organizational skills and ability to work independently, flexibly and reliably, prioritizing accordingly to the company objectives
- Experience in a project leadership role while not essential is highly desirable
- Team player who collaborates and communicates effectively in a team environment. Comfortable sharing knowledge with wider company team and, as appropriate, report work to the scientific or industry community
- Innovative, entrepreneurial, and enjoys working in a fast-paced environment
- State-of-the-art campus environment with on campus restaurant and Montessori nursery
- Flexible working environment
- Competitive reward including annual company bonus
- Employee recognition schemes
- 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
- Employer contribution to pension (employee does not have to contribute)
- Life assurance cover 4x basic salary
- Private Medical Insurance, including optical and dental cover.
- Group income protection
- Employee assistance program
- Health Cash Plan
- Access to company subsidized gym membership.
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
- Cycle to work scheme
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
