Senior Medicinal Chemist
3 hours ago
Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability.
We are seeking a talented and highly motivated Principal Scientist, Medicinal Chemistry with relevant drug discovery experience to join our team.
Key Responsibilities- Design and execute medicinal chemistry strategies to support biology validation and drug discovery from hit finding to lead generation, lead optimization, and candidate selection.
- Discover and advance novel chemical entities (small molecules, protacs, molecular glues) into clinical development.
- Provide strategic, scientific, and managerial leadership to external CRO med chem teams.
- Serve as project and chemistry lead for drug discovery programs.
- Collaborate with the IP team to create and execute strategy to establish, protect, and expand intellectual property.
- Communicate, collaborate, and coordinate effectively within cross-functional teams.
- Effectively present and communicate research findings at internal meetings and external scientific conferences.
- Ph.D. in Organic Chemistry or Medicinal Chemistry with a minimum of 10+ years of relevant drug discovery experience in the biotech/pharmaceutical industry.
- Experienced in all aspects of medicinal chemistry, including use of tool/probe compounds, hit ID and follow-up, hit-to-lead chemistry, and lead optimization to candidate selection.
- Broad background in all aspects of drug discovery, including SBDD, physicochemical property-driven optimization (MPO), and computational chemistry.
- Working knowledge of structural biology, ADME/PK, in vitro assays, and in vivo pharmacology.
- Experience in managing and building strong relationships with chemistry CROs.
- Demonstrated success in leading medicinal chemistry and projects teams to deliver high-quality compounds into development.
- Experience in oligonucleotide drug discovery is a plus.
- Track record of delivering on project and company goals.
- Ability to accommodate to rapidly changing priorities and deadlines.
- Excellent communication and project leadership skills and ability to work effectively in a cross-functional team setting.
- Proven track record for striving for a high level of innovation and scientific excellence.
Location: Cambridge, MA
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