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Senior Medicinal Chemist

2 months ago


Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full time
About the Role

Bicycle Therapeutics is a clinical-stage biopharmaceutical company dedicated to developing innovative medicines for underserved diseases. We are seeking a highly skilled Senior Medicinal Chemist to join our team and contribute to the design and synthesis of bioactive peptides and conjugates in preclinical drug discovery programs.

Key Responsibilities
  • Manage external resources to deliver on synthetic and analytical tasks, working collaboratively with the scientific team in a project team environment to progress Bicycle's oncology pipeline.
  • Design and synthesize bioactive Bicycle peptides to a set Target Product Profile, driving chemistry activities within a project team.
  • Serve on internal project teams, communicate with project team and colleagues effectively, and work well with others to meet experimental and organizational goals.
  • Present the results of independently conducted research effectively in oral or written form to line manager, project team members, and management level meetings.
  • Manage chemistry at external contract research organizations (CROs), including maintaining a good relationship, development of detailed chemistry plans, project tracking, data and compound management, critical evaluation of results, and analytical data interpretation.
Requirements
  • Relevant industry or academic experience in contemporary medicinal/peptide chemistry and in the design and synthesis of bioactive peptides and conjugates in preclinical drug discovery programs.
  • Experience in structure-based drug design and the use of computational modeling and data analysis software to interpret SAR data (activity, selectivity, DMPK characteristics, physical properties, etc.).
  • Demonstrated experience in managing external (CRO, CMO) resources to accomplish project tasks.
  • Experience in a project leadership role, although not essential, is highly desirable.
  • Comfortable sharing knowledge with the wider company team and, as appropriate, reporting work to the scientific or industry community.
What We Offer
  • A state-of-the-art campus environment with on-campus restaurant and Montessori nursery.
  • Flexible working environment.
  • Competitive rewards, including an annual company bonus.
  • Employee recognition schemes.
  • 28 days annual leave in addition to bank holidays, plus the option to buy up to 5 additional days annually.
  • Employer contribution to pension (employee does not have to contribute).
  • Life assurance cover 4x basic salary.
  • Private Medical Insurance, including optical and dental cover.
  • Employee assistance program.
  • Health Cash Plan.
  • Access to company-subsidized gym membership.
  • Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
  • Cycle to work scheme.