Principal Research Scientist, Medicinal Chemistry

5 days ago


Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full time
Job Summary

We are seeking a highly skilled Principal Scientist to join our dynamic Medicinal Chemistry team at Bicycle Therapeutics. As a key member of our team, you will be responsible for designing and synthesizing novel Bicycles and conjugates to deliver clinical candidates.

Key Responsibilities
  • Project Leadership: Manage chemistry activities within project teams, including the design of bioactive Bicycle peptides to a set Target Product Profile.
  • Collaboration and Communication: Serve on internal project teams, communicate effectively with project team members and colleagues, and work well with others to meet experimental and organizational goals.
  • Research and Development: Present research results effectively in oral or written form to line managers, project team members, and management-level meetings.
  • External Partnerships: Manage chemistry at external contract research organizations (CROs), including maintaining relationships, developing chemistry plans, project tracking, data and compound management, critical evaluation of results, and analytical data analysis.
  • Intellectual Property: Prepare reports and contribute to drafting and reviewing patent filings.
  • Publication: Prepare manuscripts for submission to peer-reviewed journals.
  • Innovation: Introduce and develop new innovations that expand the company's platform.
Requirements
  • Experience: Relevant industry or academic experience in contemporary medicinal/peptide chemistry and in the design and synthesis of bioactive peptides and conjugates in preclinical drug discovery programs.
  • Skills: Experience in structure-based drug design, computational modeling, and data analysis software to interpret SAR data.
  • Desirable: Experience in developing drug conjugates or radiopharmaceuticals, managing external resources, and project leadership.
  • Personal Qualities: Excellent organizational skills, ability to work independently, flexibly, and reliably, prioritizing accordingly to company objectives.
  • Team Player: Collaborate and communicate effectively in a team environment, comfortable sharing knowledge with the wider company team and, as appropriate, reporting work to the scientific or industry community.
  • Innovative: Enjoy working in a fast-paced environment and be innovative, entrepreneurial, and comfortable with change.
What We Offer
  • State-of-the-Art Campus: A dynamic and modern work environment with on-campus amenities.
  • Flexible Working: A flexible working environment that supports work-life balance.
  • Competitive Rewards: A competitive reward package, including annual company bonus, employee recognition schemes, and opportunities for professional growth.
  • Benefits: A comprehensive benefits package, including 28 days annual leave, employer contribution to pension, life assurance cover, private medical insurance, group income protection, employee assistance program, health cash plan, and access to company-subsidized gym membership.
  • Share Options: Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
  • Cycle to Work Scheme: A cycle-to-work scheme to promote sustainable transportation.


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