Research Scientist

4 days ago

Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full time
About the Role

We are seeking a highly skilled Research Scientist to join our dynamic and fast-paced Medicinal Chemistry team at Bicycle Therapeutics. As a key member of our team, you will be responsible for the design and synthesis of novel Bicycles and conjugates, with a focus on developing lead candidates for our oncology pipeline.

Key Responsibilities
  • Design and synthesize novel Bicycles and conjugates, with a focus on developing lead candidates for our oncology pipeline.
  • Manage external resources to deliver on synthetic and analytical tasks, including contract research organizations (CROs) and contract manufacturing organizations (CMOs).
  • Work collaboratively with the scientific team in a project team environment to progress our oncology pipeline.
  • Contribute to the chemical optimization of Bicycle monomers and the design and synthesis of Bicycle oncology agents.
  • Present research results effectively in oral or written form to line manager, project team members, and management level meetings.
  • Coordinate chemistry activities at external CROs, including maintaining relationships, developing chemistry plans, project tracking, data and compound management, evaluation of results, and analytical data analysis.
  • Prepare reports and contribute to drafting patent filings and journal manuscripts.
Requirements
  • Relevant industry or academic experience in contemporary medicinal chemistry and in the design and synthesis of bioactive peptides and conjugates in preclinical drug discovery programs.
  • Experience in interpreting SAR data desirable (activity, selectivity, DMPK characteristics, physical properties, etc.).
  • Demonstrated experience in managing external resources to accomplish project tasks.
  • Excellent organizational skills and ability to work independently, flexibly, and reliably, prioritizing accordingly to the company objectives.
  • Team player who collaborates and communicates effectively in a team environment, comfortable sharing knowledge with the wider company team and, as appropriate, reporting work to the scientific or industry community.
  • Innovative, entrepreneurial, and enjoys working in a fast-paced environment.
Desirable Qualifications
  • Experience in peptide chemistry research.
  • Experience in developing drug conjugates or radiopharmaceuticals.
  • Use of structure-based drug design and the use of computational modeling and data analysis software to support drug development activities.
What We Offer
  • A state-of-the-art campus environment with on-campus restaurant and Montessori nursery.
  • Flexible working environment.
  • Competitive rewards, including an annual company bonus.
  • Employee recognition schemes.
  • 28 days annual leave, in addition to bank holidays, plus the option to buy up to 5 additional days annually.
  • Employer contribution to pension.
  • Life assurance cover 4x basic salary.
  • Private Medical Insurance, including optical and dental cover.
  • Group income protection.
  • Employee assistance program.
  • Health Cash Plan.
  • Access to company-subsidized gym membership.
  • Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
  • Cycle to work scheme.
About Us

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We are an equal opportunities employer and welcome applications from all qualified candidates. We do not discriminate on the basis of race, religion, color, gender, sexual orientation, age, disability status, marital status, or veteran status.

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