Pharmacology Research Scientist
2 months ago
We are seeking an experienced and passionate Senior Scientist to join our Drug Discovery team at Cancer Research UK. As a key member of our Mechanistic Pharmacology team, you will play a leading role in the design, development, and analysis of biochemical assays, including bespoke mechanistic data and High Throughput Screening activities.
Key Responsibilities- Design and develop physiologically relevant biochemical assays in 384 well and 1536 well plate format to characterise cancer targets in detail at the molecular level.
- Enable high-throughput screening, profile the structure-activity and structure-kinetic relationships of small molecules, and characterise their mechanism of action to inform dose prediction and clinical efficacy.
- Drive innovative ways of working through keeping abreast of cutting-edge biochemistry, enzymology, and HTS science.
- Form an integral part of the Cancer Research Horizon Drug Discovery team working alongside our industry and academic partners to progress novel cancer targets towards patient benefit.
- A BSs, MSc or PhD in biological science such as biochemistry or pharmacology; relevant experience may be substituted for education.
- Significant experience in a drug discovery environment of assay development including dissecting enzyme and small molecule inhibitor mechanisms for a range of target classes.
- Detailed theoretical and practical understanding of biochemical assays and detection technologies, with a particular focus on physiologically relevant systems.
- Significant experience in liquid handling and automated dispensing.
- Significant experience of analysing large datasets with appropriate statistical rigour.
- Experience of running biochemical and cell-based high throughput screens of small molecules in 384 well and 1536 well plate format is desirable.
- Additional experience in prosecution and robust statistical analysis of high throughput screening data would be desirable.
We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities, and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career, and achieve your personal wellbeing goals.
You can explore our benefits by visiting our careers web page.
-
Cambridge, Cambridgeshire, United Kingdom Cancer Research UK Full timeAbout the RoleCancer Research UK is seeking an experienced Senior Scientist to join our Drug Discovery team. As a key member of our Mechanistic Pharmacology team, you will play a crucial role in designing, developing, and analysing biochemical assays to characterise cancer targets and inform drug discovery strategies.Key ResponsibilitiesDesign and develop...
-
Senior Cellular Pharmacology Expert
1 week ago
Cambridge, Cambridgeshire, United Kingdom Cancer Research UK Full timeJob SummaryWe are seeking a highly skilled and experienced Senior Cellular Pharmacology Expert to lead our Cell Pharmacology team and drive the development of cellular assay development, SAR and SKR profiling, and impactful mechanistic insight to projects at the cellular level using quantitative cellular pharmacology.The ideal candidate will have a strong...
-
Group Leader
5 days ago
Cambridge, Cambridgeshire, United Kingdom CANCER RESEARCH UK Full timeAbout the RoleIn this exciting opportunity, we are seeking an accomplished scientific and people leader to lead the Cell Pharmacology team within Mechanistic Pharmacology at our Babraham Research Campus facilities in Cambridge.As the Group Leader, Cell Pharmacology, you will be responsible for leading and driving a high-performing team to provide all aspects...
-
Research Scientist
1 month ago
Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full timeJob Title: Investigator ScientistMedical Research Council is seeking a highly skilled Investigator Scientist to join our team. As an Investigator Scientist, you will play a key role in undertaking cutting-edge research in early human embryo development.Key Responsibilities:Conduct research aimed at identifying the molecular mechanisms underlying embryo...
-
Research Scientist
1 month ago
Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full timeJob Title: Investigator ScientistMedical Research Council is seeking a highly skilled Investigator Scientist to join our team. As an Investigator Scientist, you will play a key role in undertaking cutting-edge research in early human embryo development.Key Responsibilities:Conduct research aimed at identifying the molecular mechanisms underlying embryo...
-
Research Scientist
2 weeks ago
Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full timeJob Title: Investigator ScientistJob Summary:We are seeking a highly skilled and motivated Investigator Scientist to join our research team at the Medical Research Council. The successful candidate will be responsible for conducting cutting-edge research in early human embryo development, with a focus on identifying the molecular mechanisms underlying embryo...
-
Research Scientist
1 month ago
Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full timeJob Title: Investigator ScientistJob Summary:We are seeking a highly skilled and experienced Investigator Scientist to join our research team at the Medical Research Council. The successful candidate will be responsible for conducting cutting-edge research in early human embryo development, with a focus on identifying the molecular mechanisms underlying...
-
Research Scientist
1 month ago
Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full timeJob Title: Investigator ScientistJob Summary:We are seeking a highly skilled and experienced Investigator Scientist to join our research team at the Medical Research Council. The successful candidate will be responsible for conducting cutting-edge research in early human embryo development, with a focus on identifying the molecular mechanisms underlying...
-
Research Scientist
1 month ago
Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full timeJob Title: Investigator ScientistJob Summary:We are seeking a highly skilled and experienced Investigator Scientist to join our research team at the Medical Research Council. The successful candidate will be responsible for undertaking cutting-edge research in early human embryo development, with a focus on identifying the molecular mechanisms that underlie...
-
Research Scientist
1 month ago
Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full timeJob Title: Investigator ScientistJob Summary:We are seeking a highly skilled and experienced Investigator Scientist to join our research team at the Medical Research Council. The successful candidate will be responsible for undertaking cutting-edge research in early human embryo development, with a focus on identifying the molecular mechanisms that underlie...
-
Research Scientist
4 weeks ago
Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full timeJob Title: Investigator ScientistJoin the Medical Research Council as an Investigator Scientist and contribute to cutting-edge research in early human embryo development.Key Responsibilities:Undertake innovative research to identify molecular mechanisms underlying embryo plasticity.Develop and apply novel approaches to solve complex problems in...
-
Research Scientist
4 weeks ago
Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full timeJob Title: Investigator ScientistJoin the Medical Research Council as an Investigator Scientist and contribute to cutting-edge research in early human embryo development.Key Responsibilities:Undertake innovative research to identify molecular mechanisms underlying embryo plasticity.Develop and apply novel approaches to solve complex problems in...
-
Research Scientist
1 month ago
Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full timeJob Title: Investigator ScientistJob Summary:We are seeking a highly skilled and motivated Investigator Scientist to join our research group at the Medical Research Council. The successful candidate will be responsible for undertaking cutting-edge research in early human embryo development, with a focus on identifying the molecular mechanisms underlying...
-
Research Scientist
1 month ago
Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full timeJob Title: Investigator ScientistJob Summary:We are seeking a highly skilled and motivated Investigator Scientist to join our research group at the Medical Research Council. The successful candidate will be responsible for undertaking cutting-edge research in early human embryo development, with a focus on identifying the molecular mechanisms underlying...
-
Research Scientist
2 weeks ago
Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full timeJob Title: Investigator ScientistJob Summary:We are seeking a highly skilled Investigator Scientist to join our research team at the Medical Research Council. The successful candidate will be responsible for conducting cutting-edge research in early human embryo development, with a focus on identifying the molecular mechanisms underlying embryo...
-
Research Scientist
2 weeks ago
Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full timeJob Title: Investigator ScientistJob Summary:We are seeking a highly skilled Investigator Scientist to join our research team at the Medical Research Council. The successful candidate will be responsible for conducting cutting-edge research in early human embryo development, with a focus on identifying the molecular mechanisms underlying embryo...
-
Research Scientist
1 week ago
Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full timeJob SummaryWe are seeking a highly skilled Research Scientist to join our team at the Medical Research Council. The successful candidate will be responsible for undertaking cutting-edge research in early human embryo development, with a focus on identifying the molecular mechanisms that underlie embryo plasticity.Key ResponsibilitiesConduct independent...
-
Machine Learning Research Scientist
1 month ago
Cambridge, Cambridgeshire, United Kingdom Flagship Pioneering Full timeUnlock the Potential of Immunology ResearchAt Flagship Pioneering, we're pushing the boundaries of bioplatform development with our cutting-edge MIMIC platform. This innovative approach combines machine learning with molecular mimicry to engineer therapeutics that trigger a desired biological response. Our recent collaboration with Novo Nordisk has taken...
-
Machine Learning Research Scientist
1 month ago
Cambridge, Cambridgeshire, United Kingdom Flagship Pioneering Full timeUnlock the Potential of Immunology ResearchAt Flagship Pioneering, we're pushing the boundaries of bioplatform development with our cutting-edge MIMIC platform. This innovative approach combines machine learning with molecular mimicry to engineer therapeutics that trigger a desired biological response. Our recent collaboration with Novo Nordisk has taken...
-
Postdoctoral Research Scientist
2 weeks ago
Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full timeJob Summary:We are seeking a highly motivated and experienced Postdoctoral Scientist to join our team at the Medical Research Council. The successful candidate will have a strong background in a relevant subject and a proven track record of research achievements.Key Responsibilities:The Postdoctoral Scientist will be responsible for determining the direction...
