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Research Scientist
2 months ago
We are seeking a highly skilled Research Scientist to join our dynamic and fast-paced Medicinal Chemistry team at Bicycle Therapeutics. As a key member of our team, you will be responsible for the design and synthesis of novel Bicycles and conjugates, with a focus on developing lead candidates for our oncology pipeline.
Key Responsibilities- Design and synthesize novel Bicycles and conjugates, with a focus on developing lead candidates for our oncology pipeline.
- Manage external resources to deliver on synthetic and analytical tasks, including contract research organizations (CROs) and contract manufacturing organizations (CMOs).
- Work collaboratively with the scientific team in a project team environment to progress our oncology pipeline.
- Develop and implement structure-based design strategies to optimize lead compounds.
- Present research results effectively in oral or written form to line managers, project team members, and management-level meetings.
- Coordinate chemistry activities at external CROs, including project tracking, data and compound management, and evaluation of results.
- Relevant industry or academic experience in contemporary medicinal chemistry and the design and synthesis of bioactive peptides and conjugates in preclinical drug discovery programs.
- Experience in interpreting SAR data, including activity, selectivity, DMPK characteristics, and physical properties.
- Demonstrated experience in managing external resources to accomplish project tasks.
- Excellent organizational skills and ability to work independently, flexibly, and reliably, prioritizing accordingly to company objectives.
- Team player who collaborates and communicates effectively in a team environment, comfortable sharing knowledge with the wider company team and, as appropriate, reporting work to the scientific or industry community.
- Experience in peptide chemistry research.
- Experience in developing drug conjugates or radiopharmaceuticals.
- Use of structure-based drug design and computational modeling and data analysis software to support drug development activities.
Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Our constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development.
We are headquartered in Cambridge, UK, with many key functions and members of our leadership team located in Cambridge, MA. Our company culture is key, and all Bicycle employees actively embrace and role model our company values.
What We Offer- A state-of-the-art campus environment with on-campus restaurant and Montessori nursery.
- A flexible working environment.
- Competitive rewards, including an annual company bonus.
- Employee recognition schemes.
- 28 days annual leave, in addition to bank holidays, plus the option to buy up to 5 additional days annually.
- Employer contribution to pension.
- Life assurance cover 4x basic salary.
- Private Medical Insurance, including optical and dental cover.
- Group income protection.
- Employee assistance program.
- Health Cash Plan.
- Access to company-subsidized gym membership.
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
- Cycle to work scheme.
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, color, gender, sexual orientation, age, disability status, marital status, or veteran status.
