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Research Scientist

2 months ago


Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full time
Job Description

Bicycle Therapeutics is a clinical-stage biopharmaceutical company dedicated to developing innovative medicines for underserved diseases. We are seeking a highly skilled Research Scientist to join our dynamic team and contribute to the design and synthesis of novel Bicycles and conjugates.

Key Responsibilities
  • Design and synthesis of novel Bicycles and conjugates for lead candidate development
  • Manage external resources to deliver on synthetic and analytical tasks
  • Collaborate with the scientific team in a project team environment to progress Bicycle's oncology pipeline
  • Contribute to the chemical optimization of Bicycle monomers and the design and synthesis of Bicycle oncology agents via external CRO partners
  • Support chemistry activities within a project team, including the design of bioactive Bicycle peptides to a set Target Product Profile
  • Serve on internal project teams, communicate with project team and colleagues effectively, and work well with others to meet experimental and organizational goals
  • Present research results effectively in oral or written form to line manager, project team members, and management level meetings
  • Coordinate chemistry at external contract research organizations (CROs), including maintaining a good relationship, development of chemistry plans, project tracking, data and compound management, evaluation of results, and analytical data
Requirements
  • Relevant industry or academic experience in contemporary medicinal chemistry and in the design and synthesis of bioactive peptides and conjugates in preclinical drug discovery programs
  • Experience in interpreting SAR data desirable (activity, selectivity, DMPK characteristics, physical properties, etc.)
  • Demonstrated experience in managing external (CRO, CMO) resources to accomplish project tasks
  • Comfortable sharing knowledge with the wider company team and, as appropriate, reporting work to the scientific or industry community
  • Experience in peptide chemistry research is highly desirable
  • Use of structure-based drug design and the use of computational modeling and data analysis software to support drug development activities
What We Offer
  • A state-of-the-art campus environment with on-campus restaurant and Montessori nursery
  • Flexible working environment
  • Competitive rewards, including annual company bonus
  • Employee recognition schemes
  • 28 days annual leave, plus bank holidays, and option to buy up to 5 additional days annually
  • Employer contribution to pension (employee does not have to contribute)
  • Life assurance cover 4x basic salary
  • Private Medical Insurance, including optical and dental cover
  • Employee assistance program
  • Health Cash Plan
  • Access to company-subsidized gym membership
  • Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc
  • Cycle to work scheme