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Lead Scientist, Medicinal Chemistry

2 months ago


Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full time
Job Summary

We are seeking a highly skilled Principal Scientist to join our dynamic Medicinal Chemistry team at Bicycle Therapeutics. As a key member of our team, you will be responsible for designing and synthesizing novel Bicycles and conjugates to deliver clinical candidates.

Key Responsibilities
  • Project Leadership: Manage chemistry activities within project teams, including the design of bioactive Bicycle peptides to a set Target Product Profile.
  • Collaboration and Communication: Serve on internal project teams, communicate effectively with project team members and colleagues, and work well with others to meet experimental and organizational goals.
  • Research and Development: Present research results effectively in oral or written form to line managers, project team members, and management-level meetings.
  • External Partnerships: Manage chemistry at external contract research organizations (CROs), including maintaining relationships, developing chemistry plans, project tracking, data and compound management, critical evaluation of results, and analytical data analysis.
  • Intellectual Property: Prepare reports and contribute to drafting and reviewing patent filings.
  • Publication and Presentation: Prepare manuscripts for submission to peer-reviewed journals.
  • Innovation and Growth: Introduce and develop new innovations that expand the company's platform.
Requirements
  • Experience: Relevant industry or academic experience in contemporary medicinal/peptide chemistry and in the design and synthesis of bioactive peptides and conjugates in preclinical drug discovery programs.
  • Skills: Experience in structure-based drug design, computational modeling, and data analysis software to interpret SAR data.
  • Desirable Qualifications: Experience in developing drug conjugates or radiopharmaceuticals, managing external resources, and project leadership.
  • Personal Qualities: Excellent organizational skills, ability to work independently, flexibly, and reliably, prioritizing accordingly to company objectives.
  • Team Player: Collaborate and communicate effectively in a team environment, comfortable sharing knowledge with the wider company team and, as appropriate, reporting work to the scientific or industry community.
  • Innovative and Entrepreneurial: Enjoy working in a fast-paced environment and be innovative and entrepreneurial in approach.
What We Offer
  • State-of-the-Art Campus Environment: On-campus restaurant and Montessori nursery.
  • Flexible Working Environment.
  • Competitive Rewards: Annual company bonus, employee recognition schemes, and more.
  • Employee Benefits: 28 days annual leave, employer contribution to pension, life assurance cover, private medical insurance, and more.