Associate Researcher in Cancer Biology

3 weeks ago


Cambridge, Cambridgeshire, United Kingdom Cancer Research UK Cambridge Institute Full time

Position Overview: The Cancer Research UK Cambridge Institute is looking for a dedicated and innovative Research Associate at the post-doctoral level. This role is ideal for individuals with expertise in pancreatic cancer research, particularly those proficient in CRISPR technologies, cellular biology, tissue culture, and murine studies.

Research Focus: The successful candidate will join a dynamic team focused on investigating and targeting the tumor microenvironment associated with pancreatic cancer. The laboratory employs a combination of ex vivo human and murine pancreatic tumor organoid/fibroblast co-cultures alongside murine in vivo models to explore the interactions between pancreatic cancer cells and their surrounding environment.

Key Techniques: The research will involve various advanced methodologies, including:

  • Development of orthotopic transplantation models of pancreatic cancer
  • Flow cytometry and sorting
  • Single-cell and bulk RNA sequencing
  • Multiplexed immunohistochemistry
  • RNA in situ hybridization
  • Microscopy
  • Drug and CRISPR strategies in organoids and fibroblasts
  • Pre-clinical studies in genetically engineered mouse models
  • Analysis of human pancreatic tissues

Candidate Profile: The ideal candidate will be nearing completion of a PhD in a relevant field and possess a robust background in molecular and cellular biology. Essential skills include:

  • Proficiency in tissue culture and CRISPR/Cas9 techniques
  • Experience with flow cytometry and organoid/fibroblast work
  • Familiarity with mouse models of pancreatic cancer

Only candidates with these qualifications will be considered.

Team Collaboration: Candidates are expected to thrive in a diverse and inclusive environment, demonstrating strong collaboration skills, effective communication, and creative problem-solving abilities. Contributions to other projects and intellectual engagement are highly valued.


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