Laboratory Research Associate

4 weeks ago

Cambridge, Cambridgeshire, United Kingdom University of Cambridge Full time

Position Overview: The esteemed Steve Jackson laboratory at the CRUK Cambridge Institute, affiliated with the University of Cambridge, is on the lookout for a dedicated and motivated Laboratory Research Associate.

Role Responsibilities: The successful candidate will collaborate with a skilled postdoctoral research associate on a pivotal project investigating the mechanisms of sensitivity and resistance in cancer cells subjected to clinically relevant inhibitors targeting the DNA-damage response kinase ATR. This initiative is supported by the Mark Foundation for Cancer Research.

The Research Associate will engage in high-throughput CRISPR-Cas9 screening to identify sensitivity and resistance mechanisms across specific genetic backgrounds, followed by validation and detailed mechanistic studies. Proficiency in CRISPR genome editing and/or CRISPR genetic screening is essential, alongside a robust foundation in cell and molecular biology techniques, tissue culture, and the generation of stable cell lines.

Additional Duties: The role will also encompass various responsibilities, including the preparation of reagents, maintenance of laboratory stocks, and support in the daily operations of the lab.

Candidate Profile: The ideal candidate should demonstrate initiative and independent thought, possess excellent communication abilities, and be capable of working autonomously as well as collaboratively within a dynamic and diverse team.

Preferred Qualifications:

  • Degree or equivalent in life sciences.
  • Prior experience in a molecular cell biology research environment is essential.
  • Expertise in mammalian tissue culture, including transfection, siRNA applications, and stable cell line development.
  • Familiarity with molecular biology techniques such as cloning, PCR, mutagenesis, western blotting, immunofluorescence, DNA and RNA isolation, and protein analysis.
  • Experience in lentivirus production and transduction.
  • Background in CRISPR genome editing and/or CRISPR genetic screening.
  • High attention to detail and proficient record-keeping.
  • Strong communication and organizational skills.
  • Dependability and enthusiasm.

Additional Information: The University is committed to promoting equality, diversity, and inclusion and encourages applications from all sectors of society. Furthermore, the University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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