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Laboratory Research Associate
2 months ago
Position Overview: The esteemed Steve Jackson laboratory at the CRUK Cambridge Institute, part of the University of Cambridge, is on the lookout for a motivated and talented Laboratory Research Associate.
Role Responsibilities: The successful candidate will collaborate with a skilled postdoctoral research associate on a pivotal project investigating the mechanisms of sensitivity and resistance in cancer cells subjected to clinically relevant inhibitors targeting the DNA-damage response kinase ATR. This project is generously funded by the Mark Foundation for Cancer Research.
The role involves:
- Conducting high-throughput CRISPR-Cas9 screens to identify sensitivity and resistance mechanisms in specific genetic contexts.
- Validating findings through subsequent mechanistic studies.
- Preparation of reagents and maintenance of laboratory stocks.
- Supporting the daily operations of the laboratory.
Qualifications and Skills: The ideal candidate should demonstrate initiative and independent thought, possess excellent communication abilities, and be capable of working both autonomously and collaboratively within a dynamic and diverse team.
Preferred qualifications include:
- A degree or equivalent qualification in life sciences.
- Prior experience in a molecular cell biology research environment.
- Proficiency in mammalian tissue culture techniques, including transfection, siRNA applications, and stable cell line generation.
- Familiarity with molecular biology methodologies such as cloning, PCR, mutagenesis, western blotting, immunofluorescence, and nucleic acid and protein analysis.
- Experience in lentivirus production and transduction.
- Hands-on experience with CRISPR genome editing and/or CRISPR genetic screens.
- Strong attention to detail and meticulous record-keeping.
- Effective communication and organizational skills.
- Dependability and enthusiasm for research.
Additional Information: The University is committed to promoting equality, diversity, and inclusion, and encourages applications from all segments of society. All employees must be eligible to live and work in the UK.
