Senior Computational Biologist: Protein Design Specialist

7 days ago

London, Greater London, United Kingdom Baseimmune Full time

About Baseimmune

Baseimmune is a pioneering biotechnology company revolutionizing vaccine development through cutting-edge computational antigen design. Our mission is to harness the power of data science, machine learning, and computational biology to create innovative, mutation-proof vaccines.

Job Overview

We are seeking an experienced Computational Protein Design specialist to join our Antigen Design team. The ideal candidate will have a proven track record in using deep learning methodologies, including generative AI, to design de novo protein structures. They will be experienced in developing computational pipelines to design, analyze, and validate protein structures.

Key Responsibilities

  • Drive the development of computational pipelines that use AI techniques to create proteins for use as vaccine antigens.
  • Collaborate with laboratory teams to validate and benchmark newly implemented methodologies using in silico, in vitro, and in vivo models.
  • Apply computational-based pipelines and structural expertise to design proteins presenting target epitopes in desired conformations.
  • Analyze and interpret experimental data to advance the design process.

Strategic Goals

  • Stay up-to-date with the latest research and developments within the field.
  • Critically assess advances in protein engineering and set development directions.
  • Mentor and guide junior scientists and team members.
  • Contribute to scientific publications and represent Baseimmune at scientific conferences.

Requirements

  • Ph.D. in Structural Biology, Biophysics, Computational Biology, Biochemistry, or a related field.
  • Minimum of 4 years' experience in computational protein design within an academic or industry setting.
  • Proven track record of successfully designing de novo proteins underpinned by state-of-the-art computational methodologies for biologics purposes.
  • Extensive knowledge of statistical and deep learning methods applied to protein design.
  • Experienced programming in Python and Linux command line.
  • Strong mathematical skills, problem-solving abilities, and strategic thinking.

What We Offer

  • Competitive starting salary.
  • Private medical health insurance.
  • Opportunities for career growth and professional development.
  • 26 days holiday leave + bank holidays.
  • Enhanced sick pay.
  • Pension plan.

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