Senior Research Biologist

5 days ago

London, Greater London, United Kingdom Baseimmune Full time
Job Description

Company Overview

Baseimmune is a pioneering biotechnology start-up revolutionizing vaccines through advanced computational antigen design. Our mission is to harness the fields of data science, machine learning, and computational biology to redefine cross-protective and mutation-proof vaccines.

Job Summary

We are seeking an experienced Computational Protein Design specialist to join our Antigen Design team. The ideal candidate will have a proven track record in using deep learning methodologies, including generative AI, to design de novo protein structures.

Key Responsibilities

  • Collaborate with laboratory teams to validate and benchmark newly implemented methodologies using in silico, in vitro, and in vivo models.
  • Apply computational-based pipelines and structural expertise to design proteins presenting target epitopes in desired conformations.
  • Collaborate effectively across multi-disciplinary teams, including immunologists, evolutionary biologists, molecular biologists, and ML engineers to ensure de novo designs are optimized to elicit cross-protective responses following vaccination.
  • Analyze and interpret experimental data to advance the design process.
  • Stay up to date with the latest research and developments within the field.
  • Contribute to scientific publications and represent Baseimmune at scientific conferences.

Requirements

  • Ph.D. in Structural Biology, Biophysics, Computational Biology, Biochemistry, or a related field.
  • Minimum of 4 years' experience in computational protein design within an academic or industry setting.
  • Extensive knowledge of statistical and deep learning methods applied to protein design, such as RFdiffusion, MPNN, AlphaFold, and Rosetta.
  • Experienced programming in Python and Linux command line.
  • Proven track record of scientific innovation and publications in reputable journals.

What We Offer

  • Competitive starting salary.
  • Private medical health insurance.
  • Opportunities for career growth and professional development.
  • 26 days holiday leave + bank holidays.
  • Enhanced sick pay.
  • Pension plan.

Equal Opportunities Employer

We are an equal opportunity employer and value diversity and inclusion in our workplace.

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