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Company Overview
Baseimmune is a pioneering biotechnology start-up revolutionizing vaccines through cutting-edge computational antigen design. Founded by the team that pioneered computational vaccines at the University of Oxford, our mission is to harness the power of data science, machine learning, and computational biology to redefine cross-protective and mutation-proof vaccines.
Job Summary
We are seeking an experienced Computational Protein Design specialist to join our Antigen Design team. The ideal candidate will have a proven track record in using deep learning methodologies, including generative AI, to design de novo protein structures. They will be experienced in developing computational pipelines to design, analyze, and validate protein structures.
Key Responsibilities
- Collaborate with laboratory teams to validate and benchmark newly implemented methodologies using in silico, in vitro, and in vivo models.
- Apply computational-based pipelines and structural expertise to design proteins presenting target epitopes in desired conformations.
- Collaborate effectively across multi-disciplinary teams, including immunologists, evolutionary biologists, molecular biologists, and ML engineers to ensure de novo designs are optimized to elicit cross-protective responses following vaccination.
- Analyze and interpret experimental data to advance the design process.
- Stay up to date with the latest research and developments within the field.
- Contribute to scientific publications and represent Baseimmune at scientific conferences.
Requirements
- Ph.D. in Structural Biology, Biophysics, Computational Biology, Biochemistry, or a related field.
- Minimum of 4 years' experience in computational protein design within an academic or industry setting.
- Extensive knowledge of statistical and deep learning methods applied to protein design, such as RFdiffusion, MPNN, AlphaFold, and Rosetta.
- Experienced programming in Python and Linux command line.
- Proven track record of scientific innovation and publications in reputable journals.
What We Offer
- Competitive starting salary.
- Private medical health insurance.
- Opportunities for career growth and professional development.
- 26 days holiday leave + bank holidays.
- Enhanced sick pay.
- Pension plan.
