Senior Computational Biologist: Protein Design Specialist
4 days ago
Baseimmune is a pioneering biotechnology company revolutionizing vaccine development through cutting-edge computational antigen design. Our mission is to harness the power of data science, machine learning, and computational biology to create innovative, mutation-proof vaccines.
Job OverviewWe are seeking an experienced Computational Protein Design specialist to join our Antigen Design team. The ideal candidate will have a proven track record in using deep learning methodologies, including generative AI, to design de novo protein structures.
Key Responsibilities- Develop and implement computational pipelines that utilize AI techniques to create proteins for use as vaccine antigens.
- Collaborate with laboratory teams to validate and benchmark newly implemented methodologies using in silico, in vitro, and in vivo models.
- Apply computational-based pipelines and structural expertise to design proteins presenting target epitopes in desired conformations.
- Analyze and interpret experimental data to advance the design process.
- Ph.D. in Structural Biology, Biophysics, Computational Biology, Biochemistry, or a related field.
- Minimum of 4 years' experience in computational protein design within an academic or industry setting.
- Proven track record of successfully designing de novo proteins underpinned by state-of-the-art computational methodologies for biologics purposes.
- Extensive knowledge of statistical and deep learning methods applied to protein design, such as RFdiffusion, MPNN, AlphaFold, and Rosetta.
- Experienced programming in Python and Linux command line.
- Strong mathematical skills, problem-solving abilities, and strategic thinking.
- Proven track record of scientific innovation and publications in reputable journals.
- Competitive starting salary.
- Private medical health insurance.
- Opportunities for career growth and professional development.
- 26 days holiday leave + bank holidays.
- Enhanced sick pay.
- Pension plan.
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