Research Assistant/Research Associate

3 weeks ago


Cambridge, United Kingdom University of Cambridge Full time

In vivo, cells migrate through tight spaces and may undergo division in crowded environments, both in physiological and pathological contexts, for example during immune cells diapedesis or cancer cell dissemination. These phenomena are difficult to observe in vivo, especially in mammalian models. Key studies in the field have largely exploited in vitro systems, for example culturing cells in 3D collagen matrices or microfabrication of PDMS microchannels, to mimic interstitial confining environments. From this wealth of work, it has become clear that cells experiencing physical confinement during cell migration suffer mechanical stress. This causes deformation of the largest organelle, the nucleus, and loss of nuclear integrity, thus inducing DNA damage. Physical compression can even promote genetic diversity in cancer cells. In addition, when cells in culture undergo mitosis under mechanical compression, they show extensive cortical blebbing and suffer division defects. Together, these findings show that mechanical stress negatively impacts the integrity of the genome and this has been proposed to underlie cancer initiation and progression. However, the consequences of mechanical compression on cells during in vivo cell migration remain so far unexplored.

The post-holder will carry out general lab management roles: they will oversee the maintenance of fish stocks (crossing and genotyping), day to day running of the laboratory (ordering, organization, maintaining reagents stocks, health and safety) and will contribute to the training of students.

In addition, they will be responsible for molecular biology and zebrafish transgenesis. They will characterise the novel Zebrafish lines they generate by live imaging of embryos, quantitative image analysis and immunostaining.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once the PhD has been awarded.

Informal enquiries about the position can be made to Elena Scarpa ().

Fixed-term: The funds for this post are available for 12 months.

The closing date for applications is 20 September 2024.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.


  • Research Coordinator

    2 weeks ago


    Cambridge, Cambridgeshire, United Kingdom Alzheimer's Research UK Full time

    Job SummaryThe Research Coordinator role is a key position within the Research team at Alzheimer's Research UK, a team dedicated to delivering world-class research that will lead to life-changing breakthroughs in diagnosis, prevention, treatment, and cure. The Research team is responsible for delivering an exciting new five-year strategy through a varied...


  • Cambridge, United Kingdom Alzheimer's Research UK Full time

    The Research Administrator role forms part of the Research team at Alzheimer’s Research UK, a team that is responsible for delivering world-class research that will lead to life-changing breakthroughs in diagnosis, prevention, treatment and cure. The Research team is set to deliver an exciting new five-year strategy through a varied portfolio of grant...


  • Cambridge, Cambridgeshire, United Kingdom Alzheimer's Research UK Full time

    The Research Administrator role forms part of the Research team at Alzheimer's Research UK, a team that is responsible for delivering world-class research that will lead to life-changing breakthroughs in diagnosis, prevention, treatment and cure. The Research team is set to deliver an exciting new five-year strategy through a varied portfolio of grant...

  • Research Associate

    6 days ago


    Cambridge, United Kingdom Cancer Research UK Cambridge Institute Full time

    The Ali group invites applications for a computational post-doctoral research associate. Our research aims to understand how the multicellular structure of breast tumours determines relapse, metastasis, and therapeutic response. We characterise human breast tumour ecosystems using highly multiplexed tissue analysis via imaging mass cytometry and...

  • Research Coordinator

    2 weeks ago


    Cambridge, Cambridgeshire, United Kingdom Alzheimer's Research UK Full time

    About the RoleWe are seeking a highly organized and detail-oriented Research Coordinator to join our team at Alzheimer's Research UK. As a key member of our Research team, you will provide administrative support to ensure the smooth operation of various activities, including grant funding, strategic initiatives, and meeting coordination.Key...


  • Cambridge, Cambridgeshire, United Kingdom Cancer Research UK Cambridge Institute Full time

    About the Role at Cancer Research UK Cambridge Institute Are you eager to contribute to groundbreaking advancements in cancer research? We are seeking a dedicated and skilled Scientific Associate or Senior Scientific Associate (commensurate with experience) to enhance our growing Proteomics Facility at the prestigious University of Cambridge. Why Work...

  • Research Associate

    1 month ago


    Cambridge, United Kingdom Cancer Research UK Cambridge Institute Full time

    The Biffi Laboratory at the CRUK Cambridge Institute (part of the University of Cambridge) is seeking to hire a bright, creative and motivated Research Associate (post-doctoral level), with a background in pancreatic cancer research and strong skills in CRISPR technologies, cell biology, tissue culture, and mouse work to join a team working on studying and...

  • Research Scientist

    10 hours ago


    Cambridge, Cambridgeshire, United Kingdom Cancer Research UK Cambridge Institute Full time

    About the RoleWe are seeking a highly skilled and motivated individual to join our team as a Laboratory Manager (Senior) Scientific Associate (Maternity Cover) at the Cancer Signalling and Therapeutics Laboratory, led by Group Leader Dr Pau Creixell, at the Cancer Research UK – Cambridge Institute (CRUK-CI).Key ResponsibilitiesProvide scientific support...

  • Research Scientist

    8 hours ago


    Cambridge, Cambridgeshire, United Kingdom Cancer Research UK Cambridge Institute Full time

    About the RoleWe are seeking a highly skilled and motivated individual to join our team as a Laboratory Manager (Senior) Scientific Associate (Maternity Cover) at the Cancer Signalling and Therapeutics Laboratory, led by Group Leader Dr Pau Creixell, at the Cancer Research UK – Cambridge Institute (CRUK-CI).Key ResponsibilitiesProvide scientific support...


  • Cambridge, Cambridgeshire, United Kingdom Cancer Research UK Cambridge Institute Full time

    Become a Key Contributor at the Renowned Cancer Research UK Cambridge Institute Are you passionate about advancing the fight against cancer? We are seeking a dedicated and skilled Scientific Associate or Senior Scientific Associate (commensurate with your expertise) to enhance our innovative Proteomics Facility at the prestigious University of Cambridge....


  • Cambridge, Cambridgeshire, United Kingdom Cancer Research UK Cambridge Institute Full time

    Become a Key Contributor at the CRUK Cambridge Institute Are you passionate about advancing cancer research? We are seeking a dedicated and skilled Scientific Associate or Senior Scientific Associate (based on your qualifications) to enhance our innovative Proteomics Facility at the esteemed University of Cambridge. What makes this opportunity unique: ...


  • Cambridge, Cambridgeshire, United Kingdom Cancer Research UK Cambridge Institute Full time

    Position Overview: The Cancer Research UK Cambridge Institute is looking for a dedicated and innovative Research Associate at the post-doctoral level. This role is ideal for individuals with expertise in pancreatic cancer research, particularly those proficient in CRISPR technologies, cellular biology, tissue culture, and murine studies. Research Focus: The...


  • Cambridge, Cambridgeshire, United Kingdom Cancer Research UK Cambridge Institute Full time

    Position Overview: The Cancer Research UK Cambridge Institute is seeking a dedicated and skilled research assistant to contribute to our dynamic tumour immunology team. This role focuses on exploring the influence of innate lymphoid cells in immune regulation concerning tissue homeostasis, inflammatory conditions, and cancer. Key Responsibilities: Assist in...

  • Research Assistant

    3 months ago


    Cambridge, United Kingdom University of Cambridge Full time

    Fixed-term: The funds for this post are available for 2 years or until the Grant end date (30th April 2026), whichever is earliest. A position exists for a Research Assistant/Associate working in the Department of Physics, connected to the Accelerate Programme for Scientific Discovery. The Accelerate Programme for Scientific Discovery is a high-profile...

  • Research Scientist

    9 hours ago


    Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full time

    {"Key Responsibilities": "As a Research Scientist at the Medical Research Council, you will be responsible for undertaking cutting-edge research in early human embryo development. Your key responsibilities will include:1. Conducting researchUndertake research aimed at identifying the molecular mechanisms that underlie embryo plasticity.2. Providing...

  • Research Scientist

    7 hours ago


    Cambridge, Cambridgeshire, United Kingdom Medical Research Council Full time

    {"Key Responsibilities": "As a Research Scientist at the Medical Research Council, you will be responsible for undertaking cutting-edge research in early human embryo development. Your key responsibilities will include:1. Conducting researchUndertake research aimed at identifying the molecular mechanisms that underlie embryo plasticity.2. Providing...


  • Cambridge, United Kingdom Alzheimer's Research UK Full time

    The Research Administrator role forms part of the Research team at Alzheimer’s Research UK, a team that is responsible for delivering world-class research that will lead to life-changing breakthroughs in diagnosis, prevention, treatment and cure. The Research team is set to deliver an exciting new five-year strategy through a varied portfolio of grant...

  • Research Associate

    6 days ago


    Cambridge, Cambridgeshire, United Kingdom Cancer Research UK Cambridge Institute Full time

    Job SummaryWe are seeking a highly skilled Computational Biologist to join our team at the Cancer Research UK Cambridge Institute. As a Research Associate, you will contribute to cutting-edge translational research designed to unravel the complex multicellular ecosystems that drive breast cancer.About the RoleThe successful candidate will have a strong...

  • Research Associate

    6 days ago


    Cambridge, Cambridgeshire, United Kingdom Cancer Research UK Cambridge Institute Full time

    Job SummaryWe are seeking a highly skilled Computational Biologist to join our team at the Cancer Research UK Cambridge Institute. As a Research Associate, you will contribute to cutting-edge translational research designed to unravel the complex multicellular ecosystems that drive breast cancer.About the RoleThe successful candidate will have a strong...


  • Cambridge, Cambridgeshire, United Kingdom Cancer Research UK Cambridge Institute Full time

    Position Overview: The Cancer Research UK Cambridge Institute is on the lookout for a dedicated and innovative Research Associate at the post-doctoral level. This role is ideal for individuals with expertise in pancreatic cancer research, particularly those proficient in CRISPR methodologies, cellular biology, tissue culture, and murine models. Research...