Senior Drug Discovery Scientist

2 days ago


Cambridge, Cambridgeshire, United Kingdom Amphista Therapeutics Limited Full time

About the Role

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We are seeking an experienced Senior Principal Computational Chemist to lead our computational chemistry support for multiple TPD drug programmes. The successful candidate will have a significant scientific leadership role within our Cheminformatics & Computational Chemistry team, utilising their extensive experience in computational chemistry, biomolecular structural analysis, and computational modelling techniques to advance our TPD drug programmes.

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Key Responsibilities

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• Lead the computational chemistry support for multiple TPD drug programmes, working closely with fellow computational chemists, medicinal chemists, informaticians, and the project team

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• Gather, analyse, and report on biomolecular and ternary complex structural data to derive novel insights into SAR and TPD mechanisms, including the use of 3D ligand- and structure-based computational and physics-based modelling

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• Build, evaluate, and deliver structure- and ligand-based models to advance our TPD projects, and support their use by project teams

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• Apply computer-aided drug design techniques to design targeted protein degraders, including virtual screening, bioisosteric replacements, scaffold hopping, linker design, MMPA, and de novo design

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Benefits

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A competitive salary of approximately £90,000 - £120,000 per annum, dependent on experience, plus benefits including flexible working hours, private medical insurance, life assurance, critical illness cover, health cash plan, discretionary bonus scheme, allocation of growth shares, pension scheme with employer matched contribution, and 25 days holiday plus bank holidays.

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About Us

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Amphista Therapeutics Limited is a pioneering company in the field of targeted protein degradation (TPD). Our proprietary degrader platform has shown promise in addressing the limitations of existing TPD strategies, and we are committed to developing innovative medicines for severe diseases.

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Our team comprises highly experienced drug discovery and TPD experts across both biology and chemistry disciplines, creating an ideal learning environment to advance your scientific career development quickly. This is an exciting opportunity to join a fast-growing and dynamic company developing first-in-class medicines to treat cancer and other areas of high unmet medical need.


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