Senior Director, DMPK

6 days ago

Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full time
Job Title: Senior Director, DMPK

Join our team at Bicycle Therapeutics as a Senior Director, DMPK, and take on a leadership role in our Quantitative Pharmacology group. As a key member of our team, you will be responsible for leading a small team of DMPK scientists supporting multiple projects from target identification through to candidate selection and ultimately regulatory submission.

Key Responsibilities:
  • Provide scientific leadership across all stages of the portfolio, working collaboratively with other core disciplines to support compound progression based on optimizing DMPK properties.
  • Oversee the quality and performance of all DMPK activities, including interactions with external CROs and internal project stakeholders.
  • Work closely with in-vivo pharmacology to design experiments to understand preclinical pharmacokinetic/pharmacodynamic (pk/pd) relationships.
  • Author and review DMPK-related IND documents in collaboration with the discovery team and regulatory team.
  • Manage DMPK budgets for CROs and monitor CROs to ensure delivery of quality data on time.
  • Support leadership of the Quantitative Pharmacology group and junior staff development.
Qualifications:
  • PhD in a relevant scientific discipline, such as drug metabolism, pharmacology, or pharmaceutical sciences.
  • Significant experience working on DMPK drug discovery and/or development projects with a track record of successful delivery.
  • In-depth understanding of DMPK science with additional knowledge of related disciplines.
  • Demonstrated expertise in DMPK problem-solving across drug discovery.
  • Ability to adapt your working style to suit different cultures and partner expectations in both remote and office-based environments.
  • Excellent organization and communication skills, both written and oral, with the ability to influence.
What We Offer:
  • A state-of-the-art campus environment with on-campus restaurant and Montessori nursery.
  • Flexible working environment.
  • Competitive rewards, including an annual company bonus.
  • Employee recognition schemes.
  • 28 days annual leave, plus bank holidays, with the option to buy up to 5 additional days annually.
  • Employer contribution to pension.
  • Life assurance cover 4x basic salary.
  • Private Medical Insurance, including optical and dental cover.
  • Enhanced parental leave policies.
  • Group income protection.
  • Employee assistance program.
  • Health Cash Plan.
  • Access to company-subsidized gym membership.
  • Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
  • Cycle to work scheme.

We are an equal opportunities employer and welcome applications from diverse candidates. All qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, color, gender, sexual orientation, age, disability status, marital status, or veteran status.

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