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Senior Director, DMPK
2 months ago
Join our team at Bicycle Therapeutics as a Senior Director, DMPK, and take on a leadership role in our Quantitative Pharmacology group. As a key member of our team, you will be responsible for leading a small team of DMPK scientists supporting multiple projects from target identification through to candidate selection and ultimately regulatory submission.
Key Responsibilities:- Provide scientific leadership across all stages of the portfolio, ensuring the highest quality and performance of all DMPK activities.
- Oversee interactions with external CROs and internal project stakeholders, ensuring seamless collaboration and communication.
- Work collaboratively with other core disciplines to support compound progression based on optimizing DMPK properties.
- Integrate data from multiple sources to inform on the understanding of bicyclic peptide distribution, metabolism, and excretion.
- Design experiments to understand preclinical pharmacokinetic/pharmacodynamic (pk/pd) relationships in collaboration with in-vivo pharmacology.
- Author and review DMPK-related IND documents in collaboration with the discovery team and regulatory team.
- Manage DMPK budgets for CROs and monitor their performance to ensure delivery of quality data on time.
- Support leadership of the Quantitative Pharmacology group and junior staff development.
- PhD in a relevant scientific discipline, such as drug metabolism, pharmacology, or pharmaceutical sciences.
- Significant experience working on DMPK drug discovery and/or development projects with a track record of successful delivery.
- In-depth understanding of DMPK science with additional knowledge of related disciplines.
- Demonstrated expertise in DMPK problem-solving across drug discovery.
- Ability to adapt your working style to suit different cultures and partner expectations in both remote and office-based environments.
- Excellent organization and communication skills, both written and oral, with the ability to influence.
- A state-of-the-art campus environment with on-campus restaurant and Montessori nursery.
- Flexible working environment.
- Competitive rewards, including an annual company bonus.
- Employee recognition schemes.
- 28 days annual leave, plus bank holidays, with the option to buy up to 5 additional days annually.
- Employer contribution to pension.
- Life assurance cover 4x basic salary.
- Private Medical Insurance, including optical and dental cover.
- Enhanced parental leave policies.
- Group income protection.
- Employee assistance program.
- Health Cash Plan.
- Access to company-subsidized gym membership.
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
- Cycle to work scheme.
We are an equal opportunities employer and welcome applications from all qualified candidates. All your information will be kept confidential according to EEO guidelines.
