Senior Director, DMPK

7 days ago

Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full time
Job Title: Senior Director, DMPK

Join our team at Bicycle Therapeutics as a Senior Director, DMPK, and take on a leadership role in our Quantitative Pharmacology group. As a key member of our team, you will be responsible for leading a small team of DMPK scientists supporting multiple projects from target identification through to candidate selection and ultimately regulatory submission.

Key Responsibilities:
  • Provide scientific leadership across all stages of the portfolio, working collaboratively with drug discovery medicinal chemists, biologists, pharmacologists, and toxicologists.
  • Oversee the quality and performance of all DMPK activities, including interactions with external CROs and internal project stakeholders.
  • Work closely with other core disciplines to support compound progression based on optimizing DMPK properties.
  • Integrate data from multiple sources to inform on the understanding of bicyclic peptide distribution, metabolism, and excretion.
  • Design experiments to understand preclinical pharmacokinetic/pharmacodynamic (pk/pd) relationships in collaboration with in-vivo pharmacology.
  • Author and review DMPK-related IND documents in collaboration with the discovery team and regulatory team.
  • Manage DMPK budgets for CROs and monitor CROs to ensure delivery of quality data on time.
  • Support leadership of the Quantitative Pharmacology group and junior staff development.
Qualifications:
  • PhD in a relevant scientific discipline, such as drug metabolism, pharmacology, or pharmaceutical sciences.
  • Significant experience working on DMPK drug discovery and/or development projects with a track record of successful delivery.
  • In-depth understanding of DMPK science with additional knowledge of related disciplines.
  • Demonstrated expertise in DMPK problem-solving across drug discovery.
  • Ability to adapt your working style to suit different cultures and partner expectations in both remote and office-based environments.
  • Excellent organization and communication skills, both written and oral, with the ability to influence.
What We Offer:
  • A state-of-the-art campus environment with on-campus restaurant and Montessori nursery.
  • Flexible working environment.
  • Competitive rewards, including an annual company bonus.
  • Employee recognition schemes.
  • 28 days annual leave, plus bank holidays, with the option to buy up to 5 additional days annually.
  • Employer contribution to pension.
  • Life assurance cover 4x basic salary.
  • Private Medical Insurance, including optical and dental cover.
  • Enhanced parental leave policies.
  • Group income protection.
  • Employee assistance program.
  • Health Cash Plan.
  • Access to company-subsidized gym membership.
  • Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
  • Cycle to work scheme.

We are an equal opportunities employer and welcome applications from all qualified candidates. All your information will be kept confidential according to EEO guidelines.

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