Associate Director, DMPK Expert
4 days ago
We are seeking a highly skilled Associate Director to join our team at Bicycle Therapeutics, a clinical-stage biopharmaceutical company. As an Associate Director of Drug Metabolism and Pharmacokinetics, you will play a key role in representing DMPK, designing and executing non-clinical studies in support of multiple projects from target identification through to candidate selection and ultimately regulatory submission.
Key Responsibilities- Design and implement the appropriate DMPK strategy according to the stage and needs of a project.
- Design experiments, review, interpret and present data at multifunctional project teams.
- Perform DMPK activities including interactions with external CRO's and internal project stakeholders.
- Work collaboratively with other core disciplines within a project team to support compound progression based on optimizing DMPK properties.
- Integrate data from multiple sources to inform the understanding of bicyclic peptide distribution, metabolism and excretion.
- Work closely with in-vivo pharmacology, toxicology and/or clinical pharmacology to design experiments to understand preclinical pharmacokinetic/pharmacodynamic (PK/PD) relationships and enable human efficacious dose projection.
- Track DMPK budgets for CRO's and contribute to project spending forecasts.
- MSc/PhD in relevant scientific discipline such as drug metabolism, pharmacology, pharmaceutical sciences.
- Experience working on DMPK drug discovery and/or development projects as a DMPK representative with a track record of problem solving and successful delivery across drug discovery.
- In-depth understanding of DMPK science with additional knowledge of related disciplines.
- Ability to adapt your working style to suit different cultures and partner expectations in both remote and office-based environment.
- Excellent organisation and communication skills, both written and oral, with the ability to influence.
- Hands-on experience in in vitro-in vivo extrapolation (IVIVE), PK, PK/PD, and/or physiologically based pharmacokinetic (PBPK) modeling preferred.
- Experience supporting radiopharmaceutical projects desirable.
- Experience working on peptides or macrocycles would be an advantage.
- Experience using Dotmatics would be an advantage.
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
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Associate Director, DMPK Expert
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Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full timeAbout the RoleWe are seeking a highly skilled Associate Director of Drug Metabolism and Pharmacokinetics to join our team at Bicycle Therapeutics. As a key member of our Quantitative Pharmacology group, you will be responsible for representing DMPK and designing non-clinical studies to support multiple projects from target identification through to candidate...
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Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full timeAbout the RoleWe are seeking a highly skilled Associate Director of Drug Metabolism and Pharmacokinetics to join our team at Bicycle Therapeutics. As a key member of our Quantitative Pharmacology group, you will be responsible for representing DMPK and designing non-clinical studies to support multiple projects from target identification through to candidate...
