Associate Director, DMPK Expert
7 days ago
The Associate Director of Drug Metabolism and Pharmacokinetics (DMPK) plays a crucial role in the success of our company, Bicycle Therapeutics. Reporting to the Vice President of Quantitative Pharmacology, this individual will be responsible for representing DMPK and leading the design and execution of non-clinical studies in support of multiple projects from target identification through to candidate selection and ultimately regulatory submission.
Key Responsibilities- Develop and Implement DMPK Strategies: Design and implement the appropriate DMPK strategy according to the stage and needs of a project.
- Design and Execute Experiments: Design experiments, review, interpret, and present data at multifunctional project teams.
- Collaborate with Cross-Functional Teams: Work collaboratively with other core disciplines within a project team to support compound progression based on optimizing DMPK properties.
- Integrate Data and Inform Understanding: Integrate data from multiple sources to inform the understanding of bicyclic peptide distribution, metabolism, and excretion.
- Work with In-Vivo Pharmacology and Toxicology: Work closely with in-vivo pharmacology, toxicology, and/or clinical pharmacology to design experiments to understand preclinical pharmacokinetic/pharmacodynamic (PK/PD) relationships and enable human efficacious dose projection.
- Track DMPK Budgets and Contribute to Project Spending Forecasts: Track DMPK budgets for CRO's and contribute to project spending forecasts.
- Advanced Degree in Relevant Scientific Discipline: MSc/PhD in relevant scientific discipline such as drug metabolism, pharmacology, pharmaceutical sciences.
- Experience in DMPK Drug Discovery and/or Development: Experience working on DMPK drug discovery and/or development projects as a DMPK representative with a track record of problem-solving and successful delivery across drug discovery.
- Deep Understanding of DMPK Science: In-depth understanding of DMPK science with additional knowledge of related disciplines.
- Adaptability and Communication Skills: Ability to adapt your working style to suit different cultures and partner expectations in both remote and office-based environments. Excellent organisation and communication skills, both written and oral, with the ability to influence.
- Hands-on Experience in IVIVE, PK, PK/PD, and/or PBPK Modeling: Hands-on experience in in vitro-in vivo extrapolation (IVIVE), PK, PK/PD, and/or physiologically based pharmacokinetic (PBPK) modeling preferred.
- Experience Supporting Radiopharmaceutical Projects: Experience supporting radiopharmaceutical projects desirable.
- Experience Working on Peptides or Macrocycles: Experience working on peptides or macrocycles would be an advantage.
- Experience Using Dotmatics: Experience using Dotmatics would be an advantage.
- State-of-the-art Campus Environment: State-of-the-art campus environment with on-campus restaurant and Montessori nursery.
- Flexible Working Environment: Flexible working environment.
- Competitive Rewards: Competitive reward including annual company bonus.
- Employee Recognition Schemes: Employee recognition schemes.
- Generous Leave Policy: 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually.
- Pension and Life Assurance: Employer contribution to pension (employee does not have to contribute). Life assurance cover 4x basic salary.
- Private Medical Insurance: Private Medical Insurance, including optical and dental cover.
- Enhanced Parental Leave Policies: Enhanced parental leave policies.
- Group Income Protection: Group income protection.
- Employee Assistance Program: Employee assistance program.
- Health Cash Plan: Health Cash Plan.
- Access to Company Subsidized Gym Membership: Access to company subsidized gym membership.
- Option Grant to Subscribe to Shares: Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
- Cycle to Work Scheme: Cycle to work scheme.
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
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Associate Director, DMPK Expert
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Associate Director, DMPK Expert
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Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full timeAbout the RoleWe are seeking a highly skilled Associate Director to join our team at Bicycle Therapeutics, a clinical-stage biopharmaceutical company. As an Associate Director of Drug Metabolism and Pharmacokinetics, you will play a key role in representing DMPK, designing and executing non-clinical studies in support of multiple projects from target...
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Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full timeAbout the RoleWe are seeking a highly skilled Associate Director of Drug Metabolism and Pharmacokinetics to join our team at Bicycle Therapeutics. As a key member of our Quantitative Pharmacology group, you will be responsible for representing DMPK and designing non-clinical studies to support multiple projects from target identification through to candidate...
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Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full timeAbout the RoleWe are seeking a highly skilled Associate Director of Drug Metabolism and Pharmacokinetics to join our team at Bicycle Therapeutics. As a key member of our Quantitative Pharmacology group, you will be responsible for representing DMPK and designing non-clinical studies to support multiple projects from target identification through to candidate...
