Senior Bioinformatics Scientist

24 hours ago

London, Greater London, United Kingdom Autolus Limited Full time
Job Title: Principal Scientist, Bioinformatics

Autolus Limited is seeking a highly skilled and motivated Principal Scientist in Bioinformatics and Data Management to join our Translational Medicine team. As a key member of our team, you will be responsible for leading the development and delivery of integrated analyses, including Whole Exome Sequencing (WES), RNA sequencing (RNAseq), clinico-demographic, and biomarker data from patients treated with CAR-T therapy from our pipeline.

Key Responsibilities:
  • Lead the integration of WES, RNAseq, clinico-demographic, and biomarker data from clinical trials and research studies.
  • Develop and implement pipelines and workflows for data processing and integration, ensuring high-quality data management and consistency.
  • Maintain and update databases and data management tools, ensuring data accuracy, security, and compliance with regulatory standards.
  • Perform comprehensive bioinformatics analyses, including variant calling, copy number change, differential expression analysis, pathway analysis, and biomarker discovery in the context of the clinical environment.
  • Utilize statistical and computational tools to interpret multi-omics data and generate meaningful medical and biological insights.
  • Develop and validate predictive models for patient outcomes to CAR-T therapy based on integrated data.
  • Work closely with cross-functional teams, including clinical, R&D and biostatistics groups, to support data needs and project objectives.
  • Provide bioinformatics expertise and guidance to collaborators, ensuring effective data usage and interpretation.
  • Collaborate with external partners and vendors as necessary to enhance data integration and analysis capabilities.
  • Lead the preparation of scientific manuscripts and reports based on integrated data analyses.
  • Contribute to the writing, editing, and submission of scientific publications in high-impact journals.
  • Present findings at scientific conferences, meetings, and internal forums to communicate research outcomes and advance the understanding of CAR-T therapy.
Requirements:
  • Minimum of 3 years of post-doctoral experience in bioinformatics, with a focus on multi-omics data analysis in a clinical or translational research setting.
  • Exceptional proficiency in statistical analysis and modelling, with a deep understanding of advanced statistical concepts and their applications in translational or clinical biology.
  • Extensive experience with next-generation sequencing data analysis, including WES and RNAseq.
  • Comprehensive understanding of industry standard bioinformatics tools, databases, and best practices.
  • Experience in applying best practices for data management, version control, and reproducible research.
Preferred Qualifications:
  • Ph.D. or Master's degree in Bioinformatics, Computational Biology, Genomics, or a related field.

  • Senior Bioinformatics Scientist

    2 weeks ago

    London, Greater London, United Kingdom Lifelancer Full time

    Job Summary:Lifelancer is seeking a highly skilled Senior Bioinformatics Scientist to join our team. As a Staff Scientist Bioinformatics, you will play a key role in driving the development of innovative genomics solutions used to support treatment decisions based on the cancers molecular profile, early detection, and monitoring of malignancies.Key...

  • Senior Bioinformatics Scientist

    2 weeks ago

    London, Greater London, United Kingdom Lifelancer Full time

    Job Summary:Lifelancer is seeking a highly skilled Senior Bioinformatics Scientist to join our team. As a Staff Scientist Bioinformatics, you will play a key role in driving the development of innovative genomics solutions used to support treatment decisions based on the cancers molecular profile, early detection, and monitoring of malignancies.Key...

  • Senior Investigator Scientist in Bioinformatics

    3 weeks ago

    London, Greater London, United Kingdom UK Research and Innovation Full time

    Job DescriptionWe are seeking a highly skilled and experienced Senior Investigator Scientist in Bioinformatics to join our team at UK Research and Innovation. The successful candidate will be responsible for leading research projects in computational cardiac imaging and bioinformatics, and will work closely with our team of scientists and clinicians to...

  • Senior Investigator Scientist in Bioinformatics

    3 weeks ago

    London, Greater London, United Kingdom UK Research and Innovation Full time

    Job DescriptionWe are seeking a highly skilled and experienced Senior Investigator Scientist in Bioinformatics to join our team at UK Research and Innovation. The successful candidate will be responsible for leading research projects in computational cardiac imaging and bioinformatics, and will work closely with our team of scientists and clinicians to...

  • Senior Investigator Scientist in Bioinformatics

    3 weeks ago

    London, Greater London, United Kingdom UK Research and Innovation Full time

    Job DescriptionWe are seeking a highly skilled and experienced Senior Investigator Scientist in Bioinformatics to join our team at UK Research and Innovation. The successful candidate will be responsible for leading research projects in computational cardiac imaging and bioinformatics, and will work closely with our team of scientists and clinicians to...

  • Senior Investigator Scientist in Bioinformatics

    3 weeks ago

    London, Greater London, United Kingdom UK Research and Innovation Full time

    Job DescriptionWe are seeking a highly skilled and experienced Senior Investigator Scientist in Bioinformatics to join our team at UK Research and Innovation. The successful candidate will be responsible for leading research projects in computational cardiac imaging and bioinformatics, and will work closely with our team of scientists and clinicians to...

  • Senior Bioinformatics Scientist

    7 days ago

    London, Greater London, United Kingdom Lifelancer Full time

    Job Title: Staff Scientist BioinformaticsJob Summary:We are seeking a highly skilled Staff Scientist Bioinformatics to join our team. The successful candidate will have a strong background in bioinformatics, with a focus on algorithm development, biomarkers, and oncology. The role will involve developing innovative genomics solutions to support treatment...

  • Senior Bioinformatics Scientist

    7 days ago

    London, Greater London, United Kingdom Lifelancer Full time

    Job Title: Staff Scientist BioinformaticsJob Summary:We are seeking a highly skilled Staff Scientist Bioinformatics to join our team. The successful candidate will have a strong background in bioinformatics, with a focus on algorithm development, biomarkers, and oncology. The role will involve developing innovative genomics solutions to support treatment...

  • Senior Bioinformatics Research Scientist

    2 weeks ago

    London, Greater London, United Kingdom Lifelancer Full time

    About the RoleWe are seeking a highly skilled Senior Bioinformatics Research Scientist to join our team at Lifelancer. As a Staff Scientist Bioinformatics, you will play a key role in driving the development of innovative genomics solutions used to support treatment decisions based on the cancers molecular profile, early detection, and monitoring of...

  • Senior Bioinformatics Research Scientist

    2 weeks ago

    London, Greater London, United Kingdom Lifelancer Full time

    About the RoleWe are seeking a highly skilled Senior Bioinformatics Research Scientist to join our team at Lifelancer. As a Staff Scientist Bioinformatics, you will play a key role in driving the development of innovative genomics solutions used to support treatment decisions based on the cancers molecular profile, early detection, and monitoring of...

  • Senior Bioinformatics Research Scientist

    1 month ago

    London, Greater London, United Kingdom Lifelancer Full time

    To excel as a Senior Bioinformatics Research Scientist, a robust foundation in bioinformatics is essential, particularly in the realms of algorithmic innovation, biomarker discovery, and oncology research. A strong scientific background in at least two of the following areas: Genomics, Statistics, Next Generation Sequencing, and/or High-Performance Computing...

  • Senior Bioinformatics Scientist

    1 month ago

    London, Greater London, United Kingdom Lifelancer Full time

    The Senior Bioinformatics Scientist will spearhead the creation of cutting-edge genomic solutions aimed at enhancing treatment decisions informed by the molecular characteristics of cancer, as well as facilitating early detection and ongoing monitoring of malignancies. This role primarily involves the development of innovative algorithms for next-generation...

  • Senior Bioinformatics Scientist

    1 month ago

    London, Greater London, United Kingdom Lifelancer Full time

    The Senior Bioinformatics Scientist will spearhead the creation of cutting-edge genomic solutions aimed at enhancing treatment decisions based on the molecular characteristics of cancer, facilitating early detection, and monitoring of malignancies. This role primarily involves the development of innovative algorithms for next-generation sequencing (NGS)...

  • Senior Bioinformatics Scientist

    5 days ago

    London, Greater London, United Kingdom Autolus Limited Full time

    Job Title: Principal Scientist, BioinformaticsAutolus Limited is seeking a highly skilled Principal Scientist, Bioinformatics to join our Translational Medicine team. As a key member of our team, you will be responsible for leading the development and delivery of integrated analyses, including Whole Exome Sequencing (WES), RNA sequencing (RNAseq),...

  • Senior Bioinformatics Scientist

    5 days ago

    London, Greater London, United Kingdom Autolus Limited Full time

    Job Title: Principal Scientist, BioinformaticsAutolus Limited is seeking a highly skilled Principal Scientist, Bioinformatics to join our Translational Medicine team. As a key member of our team, you will be responsible for leading the development and delivery of integrated analyses, including Whole Exome Sequencing (WES), RNA sequencing (RNAseq),...

  • Senior Investigator Scientist in Bioinformatics

    2 weeks ago

    London, Greater London, United Kingdom Lifelancer Full time

    Job SummaryWe are seeking a highly skilled and experienced investigator scientist to join our team at Lifelancer, a talent-hiring platform in Life Sciences, Pharma, and IT. As a Senior Investigator Scientist in Bioinformatics, you will play a key role in our collaboration with Calico Labs on human aging research.About the RoleThe successful candidate will...

  • Senior Investigator Scientist in Bioinformatics

    2 weeks ago

    London, Greater London, United Kingdom Lifelancer Full time

    Job SummaryWe are seeking a highly skilled and experienced investigator scientist to join our team at Lifelancer, a talent-hiring platform in Life Sciences, Pharma, and IT. As a Senior Investigator Scientist in Bioinformatics, you will play a key role in our collaboration with Calico Labs on human aging research.About the RoleThe successful candidate will...

  • Senior Bioinformatics Research Scientist

    2 weeks ago

    London, Greater London, United Kingdom Lifelancer Full time

    About the RoleWe are seeking a highly skilled Senior Bioinformatics Research Scientist to join our team at Lifelancer. As a key member of our bioinformatics team, you will play a critical role in driving the development of innovative genomics solutions used to support treatment decisions based on the cancers molecular profile, early detection, and monitoring...

  • Senior Bioinformatics Research Scientist

    2 weeks ago

    London, Greater London, United Kingdom Lifelancer Full time

    About the RoleWe are seeking a highly skilled Senior Bioinformatics Research Scientist to join our team at Lifelancer. As a key member of our bioinformatics team, you will play a critical role in driving the development of innovative genomics solutions used to support treatment decisions based on the cancers molecular profile, early detection, and monitoring...

  • Senior Bioinformatics Scientist

    1 month ago

    London, Greater London, United Kingdom Autolus Limited Full time

    Position Overview We are excited to announce a unique opportunity for a Senior Bioinformatics Scientist to join our expanding Translational Medicine team at Autolus Limited. This role is pivotal in supporting the global growth of our innovative cell and gene therapy solutions. Key Responsibilities Data Integration and Management: Oversee the amalgamation of...