Investigating Glycosaminoglycan Changes in Breast Cancer Using Recombinant Antibodies
2 weeks ago
About the Role
We are seeking a highly motivated PhD student to join our team at the University of Nottingham, focusing on the crucial role of glycosaminoglycans (GAGs) in breast cancer development.
Project Overview
Glycosaminoglycans are essential biomolecules found on virtually all cells. They play a vital role in various biological processes, including cell signaling and development. However, their dysregulation is linked to diseases like cancer. This project aims to develop novel recombinant antibodies that specifically target GAGs on breast cancer cells.
Your Responsibilities
- Utilize cutting-edge antibody phage display technology, including next-generation sequencing (NGPD), to identify and isolate highly specific antibodies against cell surface GAGs from breast cancer cell populations.
- Clone and express the identified antibody binders for further characterization.
- Evaluate the binding specificity of the recombinant antibodies against breast cancer cells and defined GAG structures.
Collaboration and Development
This studentship offers a unique opportunity to work within a dynamic research group specializing in phage display. You will collaborate with leading experts in the field, including researchers from The University of Nottingham, Liverpool University, Manchester University, the Francis Crick Institute, international partners (USA and Denmark), and commercial collaborators (InterReality Labs). This collaborative environment fosters knowledge sharing and professional development.
Qualifications and Skills
Applicants should possess a minimum of a 2.1 undergraduate degree in biological sciences or a 2.2 degree with a Master's degree in a related field.
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