Laboratory Research Specialist

4 weeks ago


Cambridge, Cambridgeshire, United Kingdom University of Cambridge Full time

We invite applications for a motivated Research Assistant / Associate to become an integral part of Dr. Heather Machado's laboratory within the Department of Pathology at the University of Cambridge. The Machado Lab focuses on the interplay between tumor and immune cells and their roles in cancer development. Utilizing evolutionary genetics and multi-omic datasets, we investigate critical questions, including the timing of immune responses to cancer, the impact of inflammation on immune remodeling, and the somatic evolution of immune responses to immunotherapy.

We are seeking a researcher to lead the establishment of laboratory protocols and oversee the lab's data generation initiatives. Key responsibilities will include tissue processing, flow cytometry, sequencing library preparation, and protocol refinement. Candidates should possess exceptional organizational skills and demonstrate the ability to work autonomously.

Appointment at the Research Associate level is contingent upon possessing a PhD; candidates without a PhD will be appointed at the Research Assistant level.

Individuals who have submitted their PhD thesis but have not yet received their degree will initially be appointed as Research Assistants, with the title transitioning to Research Associate upon PhD completion.

Required Knowledge, Skills, and Experience:

  • Proficiency in general molecular biology techniques (e.g., PCR, DNA/RNA extraction)
  • Experience with flow cytometry (or a willingness to learn)
  • Ability to troubleshoot protocols
  • Strong organizational skills, including meticulous documentation of experiments and results
  • Excellent verbal and written communication abilities
  • Capability to manage time effectively and work independently
  • Enthusiasm for collaboration in a multidisciplinary environment
  • A minimum of 2 years of relevant laboratory experience

Desired Knowledge, Skills, and Experience:

  • Experience with tissue dissociation (e.g., tumor samples)
  • Flow cytometry analysis of immune cell populations
  • Isolation of peripheral blood mononuclear cells
  • Sequencing library construction expertise
  • Familiarity with programming in R

This position is fixed-term, with funding available for an initial period of 3 years.

Upon acceptance of an employment offer, the successful candidate will be required to complete a health assessment.

The University is committed to promoting equality, diversity, and inclusion and encourages applications from all segments of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.



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