Investigator, Multiplex and Spatial Molecular

3 weeks ago

Stevenage, United Kingdom GSK Full time

**Site Name**: UK - Hertfordshire - Stevenage

**Posted Date**: Mar 13 2024

GSK is looking for exceptional Spatial Biology scientists to develop multiplex spatial immuno-assays, to be based in the Bioimaging group at our R&D site in Stevenage, UK.

In particular, the role will be focused on using cutting edge technologies that bridge imaging and omics domains to enable high-resolution, highly multiplexed localization and quantitation of targeted RNA and protein panels at single cell level or better. The data delivered by these assays will contribute to key decision-making points in projects across GSK’s portfolio from target validation to late-stage assets.

The role will additionally involve providing expert scientific input to colleagues in related imaging and genomics teams to achieve the best experimental designs for proposed projects and maximize the delivery of decision-making data obtained from critical samples, accelerating the path to effective and safe drugs that help patients to do more, feel better, and live longer.

**Bioimaging at GSK**

At our world class scientific hub in Hertfordshire, UK, our Bioimaging department brings together key areas of _in-vivo_ and _ex-vivo_ imaging combined with histology to understand both disease state and interventional drugs, combining data on drug distribution with the effect that the drug has on intact biological systems.

As well as using existing modalities we keep aware of developing technologies and analytics through an extensive internal and external network. We work closely with other Bioimaging teams, making use of expert resources available across R&D including pathologists, AI scientists, data analysts and biology specialists.

This role will provide key capabilities to the team, combining the precision of probe-based assays, the context of imaging and the scale of omics technologies to provide powerful statistically robust insights into biological processes and the effect of interventional drugs.

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.

Discover more about our company wide benefits and life at GSK on our webpage _Life at GSK | GSK_

**In this role you will**
- Deliver defined multi-modal spatial multiplexing project packages and contribute to broader packages of work in support of project teams, from conception through to data interpretation and delivery.
- Contribute technical, scientific microscopy and multi omics spatial multiplexing expertise to experimental design, lab work, computational analysis (image analysis, data analysis), and scientific interpretation of data generated, including comprehensive and timely documentation.
- Develop new methods and study designs that will provide earlier, more rapid and more clinically relevant spatial multiplexing data to improve overall project quality and reduce drug development timelines.
- Write and issue/ submit reports (company reports and scientific publications) on results obtained if required.
- Perform sample preparation and routine data acquisition procedures as appropriate. Be willing to provide hands-on lab work and technical / scientific expertise in other areas of the department/division, if required, when not engaged on priority projects in primary discipline.
- Make scientific oral and poster presentations at internal project meetings, symposia, departmental meetings, and external conferences, and contribute to the strategy of the department.

**_ Why you?_**

**Basic Qualifications & Skills**:
**We are looking for professionals with these required skills to achieve our goals**:

- Bachelor’s or Master’s degree with demonstrated role performance equivalent to a PhD or postdoc in Immunoassay, Imaging, Transcriptomics/Proteomics or related field.
- Proven ability to work in a proactive and agile way in the laboratory to conceive, design, execute and interpret immunofluorescence_, in situ_ hybridisation and _in situ_ sequencing assays using established and novel methods.
- Handling, processing and fixation (including freezing) of a variety of tissue types to ensure highest sample quality. Preparation of high-quality paraffin and cryosections.
- Deep understanding of fluorescence-based tissue-slide assay technologies and experience in generating decision-making data using these technologies.
- Understanding of the requirement for reagent and assay validation and experience in delivering high quality assays using automated staining and imaging platforms.

**Preferred Qualifications & Skills**:
**Please note the following skills are not necessary, just preferred, if you do no

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