Research Assistant

3 weeks ago

Newcastle upon Tyne, United Kingdom Newcastle University Full time

**Salary**:
**Research Assistant**: £31,396 to £32,982 per annum

**Research Associate**: £33,966 to £36,024 per annum

Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.

**Closing Date**: 07 August 2023

The Role

The appointee will play a critical role in working on a project focused on understanding the role of abnormalities in sphingolipids in Lewy body dementia (LBD). LBD is a common neurodegenerative disorder characterised by the accumulation of the protein alpha-synuclein. The proposed project will build on previous work identifying links between sphingolipid homeostasis and alpha-synuclein accumulation to determine whether abnormalities in sphingolipid homeostasis leads to aggregation of alpha-synuclein by alterations in its membrane interactions. The proposed project combines work in human post-mortem brain tissue with functional studies in relevant cell lines and primary cells using advanced imaging.

Applicants should have a PhD in a relevant area. Experience of working in human cell lines and primary cells will be considered an advantage.

This position requires a capacity and willingness to learn new laboratory techniques, enthusiasm for dementia research, attention to detail and a strong desire to perform work to a high standard, excellent record-keeping, and the ability to work well with others as part of a multi-disciplinary team. Research culture is an important goal of our laboratory, and members are expected to contribute to a positive working environment for all.
This post will involve working with human post-mortem brain tissue and antibodies derived from animals, so the appointee must be happy to work with these materials. The nature of cell culture means that working in evenings or weekends may be required from time to time.

The appointee will join a supportive team where there is a great focus on helping the members of the laboratory to meet their goals and will be supported throughout the project to develop as a researcher.

This post is full-time and fixed term for 27 months.

Key Accountabilities
- Although working under the general guidance of an academic or Principal Investigator, the postholder will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial 'added value'
- Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements
- Determine appropriate methodologies for research, with advice and support where required
- Begin to write, with appropriate support, proposals for individual research funding or, where funders do not permit this, contribute to the writing of collective bids
- Assess research findings for the need/scope for further investigations
- Contribute to the writing up of their research for publication and dissemination, either through seminar and conference presentations or through publications
- Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline
- May be involved in the supervision, with guidance, of final year undergraduate research projects and in providing support to postgraduate research students or Research Assistants
- Will need to work with the support staff and, on occasions, with undergraduate and postgraduate students, and interact intellectually with other academic members of the Institute.
- May contribute to events celebrating the public engagement of science/social sciences/humanities
- Develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment
- The nature of cell culture work and, in particular, culturing surgical resections means some out of hours working may be required from time to time

The Person (Essential)

Knowledge, Skills and Experience
- Ability to work well as part of a team and rapidly acquire new skills
- Likelihood of advanced skills directly related to the research projects
- High level of analytical and problem-solving capability
- Ability to communicate complex information with clarity and to encourage the commitment of others
- Experience of research with clear transferable skills and some experience or awareness of the research environment
- Presentations at conferences and/or high-quality publications
- Knowledge of the brain, neurodegenerative diseases, and/or sphingolipids

Desirable
- Cell culture experience (particularly of primary cells)
- Experience in performing TIRF microscopy
- Super-resolution microscopy experience

Attributes and Behaviour
- A commitment to and interest in neurodegenerative disease research
- Positive attitude to work and enthusiasm for the area of research
- Commitment to a positive research culture

Desir

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