Research and Development Biochemist

3 weeks ago

Oxford Oxfordshire, United Kingdom CyanoCapture Full time

Summary CyanoCapture is a VC-backed biotech company from the University of Oxford, using the forefront of bioengineering for carbon capture. The first-of-a-kind technology has been backed by Shell, Elon Musk's XPRIZE and Innovate UK, alongside a number of VCs and private investors.

After winning a $4 million grant from Horizon Europe, CyanoCapture is leading a consortium of 11 institutions to launch a first-of-a-kind pilot project in Portugal next year which will demonstrate the conversion of CO2 from flue gases into biocrude oil using CyanoCapture's proprietary fast-growing strains.

As the company is looking towards commercialisation in parallel to its final stages of technological development, we are seeking an ambitious individual to join the company as the Protein Biochemist to work on the de novo design, characterisation and expression of high value recombinant proteins using a new fast-growing photosynthetic bacteria. They will assist the CSO and CTO in translating the R&D from bench-to-pilot and have a keen interest in being a part of the commercialisation journey for a brand new game-changing technology for affordable carbon capture.

Media: The company has received traction from the Oil & Gas sector and press coverage from media outlets including, Sifted covering our recent work in the United Arab Emirates, The Guardian and the BBC. The Horizon project ($4 million) was awarded to a consortium of 11 institutions in Europe led by CyanoCapture, to fund the launch of a 50 T CO2/year biogenic carbon capture and biocrude production system in Portugal which will operate for a period of three years (2023 – 2027).

Your role will require you to bring your diverse technical expertise and apply it in a new field with many unknowns.

On a day-to-day basis, the role will involve mostly conducting laboratory projects to design and execute experiments involving the expression, purification and characterisation of recombinant proteins of interest. You will be responsible for bringing new ideas to the table and using a set of advanced statistical and bioinformatics tools for screening. 

Outside of your role as a protein biochemist, you will be taught our own cloning system that we use and be given the opportunity to develop skills in synthetic biology and strain engineering.
The successful candidate will enjoy the thrill of contributing intellectually to the company and also work on building novel strains of fast-growing cyanobacteria. We believe that science is done best when it can be contextualised in the real world. The kind of mindset motivated by the thrill of discovering new breakthroughs in synthetic biology and is willing to fail often and fast to get there. Lead the design and execution of experiments focused on protein expression, isolation, purification, and characterization to support ongoing research in enhancing CO2 capture efficiency and biomolecule production in cyanobacteria.
- Design and validate assays for the detection, quantification, and functional analysis of both protein and non-protein biomolecules.
- Collaborate with molecular biologists and bioengineers to integrate protein work into broader synthetic biology and metabolic engineering projects.
- Analyze experimental data using advanced statistical and bioinformatics tools, and present findings to internal teams and external collaborators.
- Contribute to the preparation of scientific manuscripts, patent applications, and grant proposals, ensuring that the company remains at the forefront of protein biochemistry and biotechnology research.
- Stay current with the latest advancements in protein biochemistry, applying new methodologies and concepts to enhance research outcomes.

PhD in Biochemistry, Molecular Biology, Structural Biology, or a related field, with a strong focus on protein chemistry. MSc graduates with a strong CV are also considered
* Proficiency in advanced analytical methods for protein quantification and analysis, such as mass spectrometry, NMR, and chromatography.
* Ability to work independently and collaboratively within an interdisciplinary research team.
* Experience mentoring junior scientists or graduate students is desirable but not required.
* Basic lab competencies (PCR, gel electrophoresis, DNA amplification, DNA assembly, cloning, BLAST)
* Strong understanding of cell biology, cloning and genetics
* Competent in statistics for life sciences research
* Basic coding experience (Python, R, C++) 

Compensation
Competitive salary + incentive structures.
25 days of paid annual leave + Bank Holidays. Travel
You may be offered opportunities to travel abroad for short durations for business, presenting research at conferences or working on pilot projects.

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