PhD Opportunity: Investigating Glycosaminoglycan Changes in Breast Cancer Cells

2 days ago

Nottingham, Nottingham, United Kingdom University of Nottingham Full time

Project Overview: This PhD position will contribute to a strategic Longer and Larger project, focusing on the development of recombinant antibodies to map pathology-related changes in glycosaminoglycans on breast cancer cells.

Background: Glycosaminoglycans play critical roles in biological processes, including cell signalling and development. However, their molecular structure and biological function are not yet fully understood.

Research Objectives: The successful candidate will isolate recombinant antibodies that bind to glycosaminoglycans, using the latest developments in antibody phage display technology and next generation sequencing.

Methodology:

The student will use next generation phage display to target cell surface glycosaminoglycans from breast cancer cell populations, identify specific binders, clone and express binders, and characterise binding against breast cancer cell populations and defined glycosaminoglycan structures.

Supervision: The PhD student will be embedded within a highly active phage-display group at the University of Nottingham and have the opportunity to interact with the whole Glycoweb team, visit collaborator's labs, and extend their research knowledge and collaborator network.

Requirements: Applicants should have a minimum of a 2.1 undergraduate biological science degree or a minimum of a 2.2 degree and a Master's degree in a related subject.

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