PhD Researcher: Glycosaminoglycan Mapping in Breast Cancer

4 hours ago


Nottingham, Nottingham, United Kingdom University of Nottingham Full time

Project Overview:

The University of Nottingham is seeking a highly motivated PhD student to join an extensive team of scientists delivering a BBSRC strategic Longer and Larger project. The team includes research groups from The University of Nottingham, Liverpool University, Manchester University, and the Francis Crick Institute, alongside international (USA and Denmark) and commercial (InterReality Labs) partners.

Research Focus:

The PhD student will focus on the development and application of recombinant antibodies to map pathology-related changes in glycosaminoglycans on breast cancer cells. Glycosaminoglycans (GAGs) are a class of biomolecules that decorate the surface of virtually all cells in the body. They play critical roles in a multitude of biological processes, including cell signalling and development, and are known to be dysregulated in disease, including cancers.

Methodology:

The studentship will use the very latest developments in antibody phage display technology, coupling the binding of vast antibody-phage libraries containing billions of potential binders with the screening power of next generation sequencing (a process termed next generation phage display, NGPD). The studentship will apply NGPD to target cell surface GAGs from breast cancer cell populations, identify specific binders, clone and express binders and finally, characterise binding against breast cancer cell populations and defined GAG structures.

Supervision:

The PhD student will be embedded within a highly active phage-display group at the University of Nottingham and have the opportunity to interact with the whole Glycoweb team, visit collaborator's labs and extend their research knowledge and collaborator network.

Requirements:

Applicants should have a minimum of a 2.1 undergraduate biological science degree or a minimum of a 2.2 degree and a Master's degree in a related subject.



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