PhD Researcher: Glycosaminoglycan Mapping and Antibody Development

2 months ago


Nottingham, Nottingham, United Kingdom University of Nottingham Full time

Project Overview:

The University of Nottingham is seeking a highly motivated PhD researcher to join an extensive team of scientists delivering a BBSRC strategic Longer and Larger project. The team includes research groups from The University of Nottingham, Liverpool University, Manchester University, and the Francis Crick Institute, alongside international (USA and Denmark) and commercial (InterReality Labs) partners.

Research Focus:

The PhD student will focus on isolating a range of recombinant antibodies that bind to glycosaminoglycans (GAGs), producing highly specific probes. The research will utilize the latest developments in antibody phage display technology, coupling the binding of vast antibody-phage libraries with the screening power of next-generation sequencing (NGPD).

Key Responsibilities:

  • Develop and apply recombinant antibodies to map pathology-related changes in GAGs on breast cancer cells
  • Utilize NGPD to target cell surface GAGs from breast cancer cell populations
  • Identify and clone specific binders, and express and characterize binding against breast cancer cell populations and defined GAG structures

Requirements:

Applicants should have a minimum of a 2.1 undergraduate biological science degree or a minimum of a 2.2 degree and a Master's degree in a related subject.

Collaboration and Training:

The PhD student will be embedded within a highly active phage-display group at the University of Nottingham and have the opportunity to interact with the whole Glycoweb team, visit collaborator's labs, and extend their research knowledge and collaborator network.



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