PhD Researcher: Glycosaminoglycan Mapping

1 month ago

Nottingham, Nottingham, United Kingdom University of Nottingham Full time

Project Title: Development and Application of Recombinant Antibodies to Map Pathology-Related Changes in Glycosaminoglycans on Breast Cancer Cells

Background: The School of Veterinary Medicine and Science at the University of Nottingham undertakes a wide range of research in biomedical sciences, including fundamental biology and population studies.

Project Description: This PhD studentship will focus on the development and application of recombinant antibodies to map pathology-related changes in glycosaminoglycans on breast cancer cells. The project will utilize next-generation phage display technology to isolate specific binders and characterize their binding against breast cancer cell populations and defined GAG structures.

Key Objectives:

  • Isolate a range of recombinant antibodies that bind to glycosaminoglycans
  • Characterize the binding of these antibodies against breast cancer cell populations and defined GAG structures
  • Develop and apply next-generation phage display technology to target cell surface glycosaminoglycans

Requirements: Applicants should have a minimum of a 2.1 undergraduate biological science degree or a minimum of a 2.2 degree and a Master's degree in a related subject.

Further Information: The PhD student will be embedded within a highly active phage-display group at the University of Nottingham and will have the opportunity to interact with the Glycoweb team, visit collaborator's labs, and extend their research knowledge and collaborator network.

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