Lead Scientific Research Officer

4 weeks ago

Glasgow, Glasgow City, United Kingdom Professor Doctor Obi Full time £28,344 - £45,357

Exploring Pyrimidine Metabolism for Cancer Prevention and Intervention

Contract Duration: Fixed for 18 months

About Us

The CRUK Scotland Institute stands as a premier cancer research facility located in Glasgow, hosting around 250 researchers distributed across 30 specialized research groups, including Principal Investigators, postdoctoral scientists, PhD candidates, and scientific officers. Recognized as one of Europe’s foremost cancer research institutions, we are dedicated to pioneering investigations into the molecular underpinnings of cancer progression. Our funding is primarily sourced from Cancer Research UK, supplemented by external grants and partnerships with industry. We pride ourselves on our reputation for exceptional fundamental cancer research, particularly in metabolism studies and advanced in vivo modeling of tumor dynamics. Our research culture emphasizes excellence, transparency, accountability, and integrity.

Research Background

Our previous investigations have indicated that modified immune and metabolic environments can promote metastasis. Notably, we have observed an increase in pyrimidine catabolism within activated neutrophils, alongside heightened levels of uridine phosphorylase 1 (UPP1)—an enzyme responsible for the conversion of uridine into uracil and ribose-1-phosphate—in neutrophils from tumor-bearing models compared to normal controls. Crucially, neutrophils exhibiting high UPP1 levels display altered behaviors that foster microenvironments conducive to cancer cell colonization.

Position Overview

We are currently seeking a Senior Scientific Officer to engage in a project focused on evaluating UPP1 in the framework of early disease and cancer prevention. Candidates should possess a degree in a scientific field pertinent to cancer biology, along with a minimum of 3 to 4 years of hands-on laboratory experience. A PhD is advantageous but not mandatory. This role may be particularly suitable for individuals who have recently completed their PhD and are awaiting viva. The project will utilize mouse models of mammary cancer, flow cytometry for immune cell population analysis, and metabolic profiling of cells and tissues. While training will be provided for flow cytometry and metabolomic techniques, ideal candidates should already have substantial experience with mouse models and preferably hold a UK Home Office Personal Licence. The project will be conducted under the guidance of Dr. Cassie Clarke, within the laboratory of Professor Jim Norman at the CRUK Scotland Institute.

Successful candidates will be expected to demonstrate independence as well as teamwork capabilities, possess strong communication and organizational skills, maintain meticulous records and database management, and exhibit a keen motivation to acquire new techniques and advance experimental efforts to enhance our understanding of immunometabolism in early disease and cancer prevention.

Employee Benefits

  • Competitive salary
  • 40.5 days of annual leave, including bank holidays (pro-rata)
  • Defined Contribution pension scheme
  • Life Insurance scheme
  • Employee Assistance Programme
  • Season ticket loan
  • Enhanced maternity pay at 6 months full pay (subject to service)
  • Shared parental leave
  • Cycle to work scheme offering savings on bicycles and accessories
  • Access to employee benefit schemes with discounts on various services
  • On-site secure parking

All applications must be submitted through our website.

Salary range: £28,344 to £45,357 based on qualifications and experience.

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