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Lead Scientific Research Officer

3 months ago

Glasgow, Glasgow City, United Kingdom Professor Doctor Obi Full time £28,344 - £45,357

Utilizing Pyrimidine Metabolism for Cancer Prevention and Intervention

Contract Duration: Fixed for 18 months

About Us

Professor Doctor Obi's institute is a prominent cancer research facility, dedicated to advancing our understanding of cancer through innovative research. With a team of approximately 250 researchers across various groups, we focus on groundbreaking studies into the molecular mechanisms underlying cancer development. Our institute is recognized for its exceptional research quality, particularly in metabolism and in vivo tumor modeling, supported by both core funding and external collaborations.

Research Background

Our investigations have revealed that changes in immune and metabolic environments can promote metastasis. Notably, we have observed an increase in pyrimidine catabolism in activated neutrophils, with heightened levels of uridine phosphorylase 1 (UPP1) in neutrophils from tumor-bearing models compared to controls. These UPP1-enriched neutrophils exhibit altered behaviors that create microenvironments conducive to cancer cell colonization.

Position Overview

We are seeking a Senior Scientific Officer to engage in a project evaluating UPP1's role in early disease and cancer prevention. Candidates should possess a degree in a scientific field relevant to cancer biology, alongside 3 to 4 years of practical laboratory experience. A PhD is advantageous but not mandatory. This role is particularly suitable for those who have recently completed their PhD and are awaiting viva. The project will involve mouse models of mammary cancer, flow cytometry for immune cell analysis, and metabolic assessments of cells and tissues. While training will be provided for specific techniques, candidates should ideally have substantial experience with mouse models and preferably hold a UK Home Office Personal Licence. The project will be conducted under the guidance of Dr. Cassie Clarke within the lab of Professor Jim Norman.

Successful candidates will demonstrate the ability to work independently and collaboratively, possess strong communication and organizational skills, and have experience in meticulous record-keeping and database management. A keen motivation to learn new techniques and advance experimental work to enhance our understanding of immunometabolism in early disease and cancer prevention is essential.

Employee Benefits

  • Competitive salary
  • 40.5 days of annual leave, including bank holidays (pro-rata)
  • Defined Contribution pension scheme
  • Life Insurance scheme
  • Employee Assistance Programme
  • Season ticket loan
  • Enhanced maternity pay at 6 months full pay (subject to service)
  • Shared parental leave
  • Cycle to work scheme offering savings on bikes and accessories
  • Access to employee benefit schemes with discounts on various services
  • On-site secure parking

All applications must be submitted through our official website.

Salary range: £28,344 to £45,357 based on qualifications and experience.