Lead Scientific Research Officer

4 weeks ago

Glasgow, Glasgow City, United Kingdom Professor Doctor Obi Full time £28,344 - £45,357

Utilizing Pyrimidine Metabolism for Cancer Prevention and Intervention

Contract Duration: Fixed for 18 months

About the Organization

Professor Doctor Obi's research institute is dedicated to advancing cancer research, located in a vibrant academic environment with a diverse team of approximately 250 researchers across various specialized groups. This institute is recognized as a leading center for cancer research in Europe, fostering innovative studies into the molecular mechanisms underlying cancer progression. In addition to core funding from prominent cancer research organizations, the institute secures a significant portion of its funding through external grants and collaborations with industry partners. The institute prides itself on its commitment to excellence, transparency, accountability, and integrity in research.

Research Background

Previous investigations have indicated that changes in immune and metabolic environments can promote metastasis. Notably, our findings reveal that the catabolism of pyrimidines is heightened in activated neutrophils, with a marked increase in the expression of uridine phosphorylase 1 (UPP1). This enzyme, responsible for cleaving uridine into uracil and ribose-1-phosphate, has been observed at elevated levels in neutrophils derived from tumor-bearing models compared to controls. Crucially, neutrophils exhibiting high UPP1 levels display altered behaviors that create microenvironments conducive to cancer cell colonization.

Position Overview

We are seeking a Senior Scientific Officer to contribute to a project focused on evaluating UPP1 within the framework of early disease and cancer prevention. Candidates should possess a degree in a scientific discipline pertinent to cancer biology, along with a minimum of 3 to 4 years of hands-on laboratory experience. While a PhD is highly desirable, it is not a strict requirement. This role may be particularly suitable for individuals who have recently completed their PhD and are awaiting their viva. The project will involve the use of mouse models for mammary cancer, flow cytometry for immune cell population analysis, and metabolic assessments of cells and tissues. Although training will be provided for flow cytometry and metabolomic techniques, ideal candidates should already have substantial experience with mouse models and preferably hold a UK Home Office Personal Licence. The project will be conducted under the guidance of a senior researcher.

Successful candidates are expected to demonstrate the ability to work independently as well as collaboratively within a team. Strong communication and organizational skills are essential, along with experience in meticulous record-keeping and database management. A keen motivation to learn new techniques and drive experimental research forward to enhance our understanding of immunometabolism in early disease and cancer prevention is crucial.

Employee Benefits

  • Competitive salary structure
  • Generous annual leave policy including public holidays (pro-rata)
  • Defined Contribution pension plan
  • Life insurance coverage
  • Employee assistance programs
  • Season ticket loan options
  • Enhanced maternity pay after 6 months of service (subject to eligibility)
  • Shared parental leave provisions
  • Cycle to work scheme offering savings on bicycles and accessories
  • Access to employee benefit schemes with discounts on various services and products
  • Secure on-site parking availability

All applications must be submitted through the designated application portal.

Salary range: £28,344 to £45,357 based on qualifications and experience.

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