Research Assistant/associate in Bioinformatics

2 weeks ago

Newcastle upon Tyne, United Kingdom Newcastle University Full time

**Salary**:
**Research Assistant**: £31,396 to £32,982 per annum

**Research Associate**: £33,966 to £44,263 per annum

Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.

**Closing Date**: 22 February 2024

The Role

In this role you will join the research teams of Dr Sarra Ryan and Professor Anthony Moorman in the development of bioinformatic pipelines for the analysis of long-read whole genome sequencing data in childhood acute lymphoblastic leukaemia. Working as part of the Leukaemia Research Cytogenetics Group, you will determine the clinical significance of novel genetic variants that are associated with childhood ALL development to improve risk-directed treatment stratification.

You will work closely with internal and external collaborators to develop and utilise tools and pipelines to process, align and analyse sequencing data produced from long read (Oxford Nanopore Technologies) and short read (Illumina) technologies. The work will be performed using high performance cloud computing solutions, including the Genomics England Trusted Research Environment. This position offers the opportunity to develop and utilise bioinformatic, biostatistic and computational methods for next generation sequencing approaches in childhood leukaemia patients.

You will have a PhD (or be near completion for appointment at Research Assistant) in Bioinformatics, Computer Science, Mathematics, Systems Biology or a similar discipline, including experience in Bioinformatics and Programming.

This appointment is a fixed term post until 31st October 2026.

Further Information about the Faculty can be found here.

Key Accountabilities
- Although working under the general guidance of an academic or Principal Investigator, the postholder will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial 'added value'
- Determine appropriate methodologies and contribute to the wider activities of research undertaken within the group, with advice and support where required
- Lead on the design, development, and deployment of novel bioinformatic and biostatistical methods required for the project
- Build internal and external contacts and participate in networks for the exchange of information and to form relationships for future collaboration
- Assess research findings for the need/scope for further investigations
- Prepare research for publication and dissemination, either through seminar and conference presentations or through publications
- Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline
- Help with the supervision of final year undergraduate research projects and postgraduate research students and where appropriate PhD students and Research Assistants
- Work with support staff, undergraduate and postgraduate students, and interact intellectually with other academic members of the Institute
- Contribute to events celebrating the public engagement of science/social sciences/humanities
- Develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment
- Contribute to broader organisational and management processes and to co-ordinate the work of other colleagues where necessary
- Where necessary, participate in the maintenance of bioinformatic hardware, software and resources (e.g. servers, Cloud computing, archiving)
- Planning and communication of analytical strategies and presentation of results to team members, expert academic user groups and collaborations within and outside of Newcastle University

The Person

Knowledge, Skills and Experience
- Knowledge of cancer genomics and genetic variation in cancer
- Knowledge, practical experience and training in bioinformatics and NGS pipeline development for the analysis of sequencing data and the identification of genetic variation in samples
- Proficient in the use of R/Bioconductor and working within a Unix/Linux environment for the analysis and presentation of NGS data
- Experienced and skilled in the use high-performance cloud computing solutions (for example AWS and the Genomics England Trusted Research Environment
- Experience with the publication of work in peer reviewed journals and presentation of findings at conferences

Desirable
- Experience with the preparation of grants for submission to funders
- Experience in the supervision of undergraduate and postgraduate students (to PhD level)
- Experience of working in a research environment

Attributes and Behaviour
- Ability to work well as part of a team or collaborators
- Ability to rapidly acquire new skills
- High level of analytical and problem-solving capability
- Excellent communication skills and ability

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