Research Assistant/associate

3 weeks ago

Newcastle upon Tyne, United Kingdom Newcastle University Full time

**Salary**: Starting

**Research Assistant**: £31,396 - £32,982 per annum

**Research Associate**: £33,966 - £36,024 per annum, with progression to £44,263 per annum

Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.

**Closing Date**: 16 July 2023

The Role

We are looking for an enthusiastic PDRA with experience of laboratory-based inflammation biology to work on a new exciting project.
We aim to understand the mechanisms of airway infection and inflammation, and importantly translate these findings in to the development of new treatments and improved delivery of care for children and young people with airway problems.

You will carry out research as part of a team working on a Medical Research Council (MRC) research project studying the airway effect of tracheostomy in children. This will involve working on the functional assessment of human blood and airway derived leukocytes, the culture and maintenance of advanced airway epithelial cell cultures and associated molecular biology techniques.

You will be responsible for the day-to-day management of experimental work to develop novel human neutrophil functional assays, including optical trap and FACS based techniques to study neutrophil functional deficiencies, investigate mechanisms and test potential therapeutic targets. The project will involve tissue culture of primary cells as well as using broad biochemical and molecular approaches.

You will work closely with other leukocyte biologists and epithelial culture specialists within the wider respiratory research group, including technicians, post-doctoral researchers and PIs from adult and paediatric respiratory and critical care research backgrounds.
The project involves collaboration with universities from the UK and Europe, including Durham, Belfast and Berlin. You will have funded training opportunities (1-2 weeks) in these external institutions to learn specific skills to bring back to Newcastle.

You will be responsible for the collection, processing, analysis, presentation (writing, graph production, image production and oral presentations at national/international conferences) and storage of experimental data in accurate, secure, detailed and up
- to-date records of all work carried out to GLP standard.

**Find out more about our Research Institutes here**:
This is a full time, fixed term 2 year post available from September 2023 with the possibility for further extension.

Key Accountabilities
Although working under the general guidance of an academic or Principal Investigator, the postholder will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial 'added value'
Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements
Determine appropriate methodologies for research, with advice and support where required
Begin to write, with appropriate support, proposals for individual research funding or, where funders do not permit this, contribute to the writing of collective bids
Assess research findings for the need/scope for further investigations
Contribute to the writing up of their research for publication and dissemination, either through seminar and conference presentations or through publications
Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline
May be involved in the supervision, with guidance, of final year undergraduate research projects and in providing support to postgraduate research students or Research Assistants
Will need to work with the support staff and, on occasions, with undergraduate and postgraduate students, and interact intellectually with other academic members of the Institute.
May contribute to events celebrating the public engagement of science/social sciences/humanities
Develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment
Develop novel blood and airway derived human neutrophil functional assays, including the use of optical traps and traditional assays, to study neutrophil functional deficiencies and test potential therapeutic targets. This will involve the generation and culture of primary airway epithelial cells as well as a wide range of molecular and cell biology techniques, including immunofluorescence, FACS, ELISA and RNA extraction, as required

The Person (Essential)

Knowledge, Skills and Experience
Essential
Ability to work well as part of a team and rapidly acquire new skills
Likelihood of advanced skills directly related to the research projects
High level of analytical and problem-solving capability
Ability to communicate complex information with clarity and

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