Research Associate in Biochemical Neuroscience and Dementia
4 weeks ago
Job Summary
The Ye lab invites applications from talented, highly motivated, and ambitious postdoctoral scientists for a Postdoctoral Research Associate (PDRA) position leading one or more projects investigating the relationship between build up and clearance of pathological protein aggregates associated with Parkinson's disease and how removal of such aggregates may be enhanced as a therapeutic strategy for disease intervention. The project will investigate proteostasis systems in post-mortem donor samples and quantify the effect of aggregate load on IPSC-derived neurons. You will use a multidisciplinary approach (maintenance and manipulation of IPSC-neurons and established cell lines, super-resolution fluorescence imaging and various biochemical techniques) to unveil the mechansim of proteostasis mechanisms and the effect of therapeutic intervention strategies on pathological aggregates. This research will be driven in close collaboration with our industry partner Eisai.
This role is part of the Department of Brain Sciences at Imperial College London.
Key Responsibilities:
- Build on your existing skills and experience to address major components of this project independently.
- Present research findings as written reports, at conferences, within the College and as published manuscripts.
- Take initiative in the planning of research, with clear and timely communications to the Group Leader and relevant researchers.
- Contribute to the smooth running of the lab and facilities, acting collegiately with other scientists, clinicians, technicians and students.
- Provide guidance to staff and assist in the supervision of undergraduate and postgraduate research students, as required.
- Maintain highly organised and accurate records of experimental work.
- Undertake appropriate scientific and professional training.
Essential Requirements:
You are a motivated and organised researcher , excited by the science we do.
With (or near completion of) a PhD in Cellular/Molecular Neuroscience with experience with IPSC cultures or in Neuropathology of Dementia (or related discipline), you will be strongly objective-driven, able to lead the project independently and put new knowledge into practice effectively.
Experimental expertise working with IPSC-differentiated neuronal culture, basic biochemistry and molecular biology is essential. Experience with advanced microscopy is a bonus.
Practical experience of quantitative image analysis, mass spectrometry or coding research projects is highly desirable in the lab.
Imperial College London is an inclusive and diverse community. We welcome applications from candidates looking to work in a collaborative and dynamic environment.
For more information about the role and requirements, please contact Dr Yu Ye.
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