Computational Chemist

6 days ago


Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full time
About the Role

Bicycle Therapeutics is a clinical-stage biopharmaceutical company dedicated to developing innovative medicines for underserved diseases. We are seeking a highly skilled Computational Chemist to join our team and contribute to the development of our novel class of medicines, referred to as Bicycle molecules.

Key Responsibilities
  • Provide computational chemistry expertise to cross-functional teams to support drug discovery projects.
  • Contribute to the ongoing development of computational chemistry technologies for drug discovery within the company.
  • Develop and implement tools and workflows to extract, integrate, analyze, and visualize chemical, biophysical, and ADMET data to support project decision-making processes.
  • Support and train members of the discovery teams in the use of analysis and visualization tools and other aspects of computational chemistry.
Requirements
  • Industry experience or postdoctoral experience in computational chemistry.
  • Practical knowledge of conducting and analyzing molecular dynamics (MD) simulations using standard software such as OpenMM, AMBER, and/or GROMACS.
  • Experience in QSAR virtual screening, ideally with peptides.
  • Experience in writing analysis scripts and pipelines in common scripting languages, such as Python, in Jupyter notebooks or as standalone scripts.
  • Knowledge of cheminformatics methods and databases.
  • Practical knowledge of quantum mechanical calculations (QM).
  • Skills in machine learning, deep learning, statistical modeling, and advanced data analytics.
About Us

Bicycle Therapeutics is a clinical-stage biopharmaceutical company dedicated to developing innovative medicines for underserved diseases. We are headquartered in Cambridge, UK, with a state-of-the-art campus environment that offers a range of benefits, including a flexible working environment, competitive rewards, and a commitment to building a diverse workforce.



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