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Senior Computational Chemist
2 months ago
Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Our company is evaluating BT8009, a Bicycle Toxin Conjugate (BTC) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist (Bicycle TICA) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, we are developing Bicycle Radio Conjugates (BRCTM) for radiopharmaceutical use and, through various partnerships, are exploring the use of Bicycle technology to develop therapies for diseases beyond oncology.
We are headquartered in Cambridge, UK, with many key functions and members of our leadership team located in Cambridge, MA. Our company culture is built on three core values:
- We are Adventurous. We believe it's the way to deliver extraordinary results for our patients.
- We are Dedicated to our Mission. You can't change the world if you don't have determination
- We are One Team. We only succeed when we work together.
Job Summary
We are seeking a highly motivated and experienced Senior Computational Chemist to join our team. As a key member of our drug discovery pipeline, you will be responsible for providing computational chemistry expertise to cross-functional teams to support drug discovery projects. You will be involved in multiple projects drawn from a range of therapeutic areas and at different stages from initial hit identification to lead optimisation.
Key Responsibilities
- Provide computational chemistry expertise to cross-functional teams to support drug discovery projects.
- Contribute to the ongoing development of computational chemistry technologies for drug discovery within the company.
- Develop and implement tools and workflows to extract, integrate, analyse and visualise chemical, biophysical and ADMET data to support our various project decision making processes.
- Support and train members of the discovery teams in the use of analysis and visualisation tools and other aspects of computational chemistry.
Qualifications
- Industry experience, or post doctorial experience in computational chemistry.
- Practical knowledge of conducting and analysis of molecular dynamics (MD) simulations using standard software such as OpenMM, AMBER and/or GROMACS, etc.
- Experience in QSAR virtual screening, ideally with peptides.
- Experience in writing analysis scripts and pipelines in common scripting languages, such as python, in Jupyter notebooks or as standalone scripts.
- Experience in amino acid and peptide modelling.
- Practical knowledge of Free Energy Perturbation (FEP) calculations.
- Use of HPC.
Additional Information
- We offer a state-of-the-art campus environment with on campus restaurant and Montessori nursery.
- We have a flexible working environment.
- We offer competitive rewards, including annual company bonus.
- We have employee recognition schemes.
- We offer 28 days annual leave in addition to bank holidays, plus the option to buy up to 5 additional days annually.
- We contribute to pension plans.
- We offer life assurance cover 4x basic salary.
- We provide private medical insurance, including optical and dental cover.
- We have group income protection.
- We offer an employee assistance program.
- We have a health cash plan.
- We offer access to company subsidized gym membership.
- We offer eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
- We have a cycle to work scheme.
