Senior Computational Chemist
3 weeks ago
We are seeking a highly skilled computational chemist with a robust background in various methodologies, including virtual screening, molecular dynamics, and the application of machine learning (ML) models to analyze and interpret diverse project data.
This role involves collaboration within a dynamic environment, engaging with multiple teams across different locations as part of our drug discovery pipeline. The ideal candidate will be self-motivated, proactive, and ambitious.
Key Responsibilities
- Engage in multiple projects across various therapeutic areas, contributing at different stages from initial hit identification to lead optimization.
- Provide computational chemistry expertise to cross-functional teams to enhance drug discovery initiatives.
- Contribute to the advancement of computational chemistry technologies for drug discovery within the organization.
- Develop and implement tools and workflows for extracting, integrating, analyzing, and visualizing chemical, biophysical, and ADMET data to inform project decision-making processes.
- Support and mentor members of the discovery teams in utilizing analysis and visualization tools, as well as other aspects of computational chemistry.
Essential:
- Experience in the industry or postdoctoral research in computational chemistry.
- Practical knowledge of conducting and analyzing molecular dynamics (MD) simulations using standard software such as OpenMM, AMBER, or GROMACS.
- Experience in QSAR virtual screening, particularly with peptides.
- Proficiency in writing analysis scripts and pipelines in common scripting languages, such as Python, in Jupyter notebooks or as standalone scripts.
- Experience in amino acid and peptide modeling.
- Practical knowledge of Free Energy Perturbation (FEP) calculations.
- Familiarity with High-Performance Computing (HPC).
Desirable:
- Knowledge of cheminformatics methods and databases.
- Practical experience with quantum mechanical calculations (QM).
- Skills in machine learning, deep learning, statistical modeling, and advanced data analytics.
- Experience in drug discovery organizations.
- State-of-the-art campus environment with on-site amenities.
- Flexible working arrangements.
- Competitive compensation package, including an annual company bonus.
- Employee recognition programs.
- 28 days of annual leave in addition to public holidays, with an option to purchase up to 5 additional days annually.
- Employer contributions to pension plans.
- Life insurance coverage at 4x the basic salary.
- Comprehensive Private Medical Insurance, including optical and dental coverage.
- Group income protection plans.
- Employee assistance programs.
- Health cash plans.
- Access to subsidized gym memberships.
- Eligibility for share options in Bicycle Therapeutics plc.
- Cycle-to-work schemes.
Bicycle Therapeutics is dedicated to fostering a diverse workforce that reflects the communities we serve. We believe that diverse and inclusive teams contribute to a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment without discrimination based on race, religion, color, gender, sexual orientation, age, disability status, marital status, or veteran status.
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