Senior Research Biologist

3 weeks ago

London, United Kingdom Baseimmune Full time

Protein Design
Team: Computational Biology
Start date: 2024, immediate
Period: Full time, permanent
Location: London Bioscience Innovation Centre in King’s Cross, London. This is a full-time role with the opportunity for fully remote or hybrid working style.

Baseimmune is a discovery stage biotechnology start-up revolutionising vaccines through advanced computational antigen design. Founded by the team that pioneered computational vaccines at the Jenner Institute, University of Oxford, our mission is to harness the fields of data science, machine learning and computational biology to redefine cross-protective and mutation-proof vaccines.

We are seeking an experienced Computational Protein Design specialist to join our Antigen Design team. The ideal candidate will have a proven track record in using deep learning methodologies, including generative AI, to design de novo protein structures. They will be experienced in developing computational pipelines to design, analyse & validate protein structures. Further, this role requires a deep understanding of protein biochemistry in the biologics space to enable effective collaboration with wet lab scientists and immunologists to both successfully design vaccine antigens and validate their effectiveness.


Scientific Goals
Collaborate with laboratory teams to validate and benchmark newly implemented methodologies using in silico, in vitro and in vivo models.
Apply computational based pipelines and structural expertise to design proteins presenting target epitopes in desired conformations.
Collaborate effectively across multi-disciplinary teams, including immunologists, evolutionary biologists, molecular biologists and ML engineers to ensure de novo designs are optimised to elicit cross-protective responses following vaccination.Analyse and interpret experimental data to advance the design process.
Stay up to date with the latest research and developments within the field
Contribute to scientific publications and represent Baseimmune at scientific conferences

D. in Structural Biology, Biophysics, Computational Biology, Biochemistry, or a related field.
~ Minimum of 4 years’ experience in computational protein design within an academic or industry setting.
~Extensive knowledge of statistical and deep learning methods applied to protein design, such as RFdiffusion, MPNN, AlphaFold and Rosetta.
~ Experienced programming in Python and Linux command line.
~ Proven track record of scientific innovation and publications in reputable journals.
~ Competitive starting salary
~ Private medical health insurance
~ Opportunities for career growth and professional development
~26 days holiday leave + bank holidays
~ Enhanced sick pay
~ Pension plan


We are an equal opportunity employer and value diversity and inclusion in our workplace.

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