Senior Computational Biologist

1 month ago


London, Greater London, United Kingdom Baseimmune Full time
Senior Computational Biologist: Protein Design

We are seeking an experienced Computational Protein Design specialist to join our Antigen Design team at Baseimmune, a discovery stage biotechnology start-up revolutionising vaccines through advanced computational antigen design.

Key Responsibilities:

  • Drive the development of computational pipelines that use AI techniques to create proteins for use as vaccine antigens.
  • Collaborate with laboratory teams to validate and benchmark newly implemented methodologies using in silico, in vitro and in vivo models.
  • Apply computational based pipelines and structural expertise to design proteins presenting target epitopes in desired conformations.
  • Collaborate effectively across multi-disciplinary teams, including immunologists, evolutionary biologists, molecular biologists and ML engineers to ensure de novo designs are optimised to elicit cross-protective responses following vaccination.

Requirements:

  • Minimum of 4 years' experience in computational protein design within an academic or industry setting.
  • Extensive knowledge of statistical and deep learning methods applied to protein design, such as RFdiffusion, MPNN, AlphaFold and Rosetta.
  • Experienced programming in Python and Linux command line.
  • Proven track record of scientific innovation and publications in reputable journals.

What we Offer:

  • Private medical health insurance.
  • Opportunities for career growth and professional development.
  • 26 days holiday leave + bank holidays.
  • Pension plan.


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