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Senior Computational Biologist
2 months ago
We are seeking an experienced Computational Protein Design specialist to join our Antigen Design team at Baseimmune. The ideal candidate will have a proven track record in using deep learning methodologies, including generative AI, to design de novo protein structures.
Key Responsibilities:
- Drive the development of computational pipelines that use AI techniques to create proteins for use as vaccine antigens.
- Collaborate with laboratory teams to validate and benchmark newly implemented methodologies using in silico, in vitro and in vivo models.
- Apply computational based pipelines and structural expertise to design proteins presenting target epitopes in desired conformations.
- Collaborate effectively across multi-disciplinary teams, including immunologists, evolutionary biologists, molecular biologists and ML engineers to ensure de novo designs are optimised to elicit cross-protective responses following vaccination.
Requirements:
- Minimum of 4 years' experience in computational protein design within an academic or industry setting.
- Extensive knowledge of statistical and deep learning methods applied to protein design, such as RFdiffusion, MPNN, AlphaFold and Rosetta.
- Experienced programming in Python and Linux command line.
- Proven track record of scientific innovation and publications in reputable journals.
What We Offer:
- Private medical health insurance.
- Opportunities for career growth and professional development.
- 26 days holiday leave + bank holidays.
- Pension plan.