Molecular Biology Researcher
1 month ago
Postdoctoral Scientist Position
We are seeking two highly motivated postdoctoral scientists to join our research group at the MRC Laboratory of Molecular Biology in Cambridge, UK. This is a three-year training and development position suitable for candidates who have recently completed their doctoral studies or those looking to transition into a new research discipline.
The primary focus of this project will be on investigating TDP-43 and annexin A11 amyloid filament formation in neurodegenerative diseases using electron cryo-microscopy (cryo-EM) and electron cryo-tomography (cryo-ET). We aim to determine the structures and molecular interactions of these filaments and develop experimental models that recapitulate TDP-43 and annexin A11 amyloid filament formation.
This project builds on our recent findings that TDP-43 forms amyloid filaments with disease-characteristic folds and that annexin A11 forms heteromeric amyloid filaments with TDP-43 in at least one type of frontotemporal dementia. We seek talented individuals who are passionate about pursuing ambitious cryo-EM projects on amyloids in neurodegenerative diseases.
Key Responsibilities:
- Investigate TDP-43 and annexin A11 amyloid filament formation using cryo-EM and cryo-ET
- Develop experimental models that recapitulate TDP-43 and annexin A11 amyloid filament formation
- Contribute to the development of new techniques and methods for studying amyloid filaments
- Collaborate with the wider scientific community at the LMB
Requirements:
- PhD in a relevant field (molecular biology, structural biology, biochemistry)
- Excellent communication and teamwork skills
- Ability to work independently and as part of a team
- Experience with cryo-EM and/or cryo-ET techniques
Salary and Benefits:
£39,375 per annum, plus benefits including a staff restaurant with roof terrace, on-site nursery, sports and social facilities, and a generous employee discount scheme.
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