Molecular Biology Researcher

2 days ago


Cambridgeshire and Peterborough, United Kingdom MRC Laboratory of Molecular Biology (LMB) Full time

Postdoctoral Scientist Position

We are seeking two highly motivated postdoctoral scientists to join our research group at the MRC Laboratory of Molecular Biology in Cambridge, UK. This is a three-year training and development position suitable for candidates who have recently completed their doctoral studies or those looking to transition into a new research discipline.

The primary focus of this project will be on investigating TDP-43 and annexin A11 amyloid filament formation in neurodegenerative diseases using electron cryo-microscopy (cryo-EM) and electron cryo-tomography (cryo-ET). We aim to determine the structures and molecular interactions of these filaments and develop experimental models that recapitulate TDP-43 and annexin A11 amyloid filament formation.

This project builds on our recent findings that TDP-43 forms amyloid filaments with disease-characteristic folds and that annexin A11 forms heteromeric amyloid filaments with TDP-43 in at least one type of frontotemporal dementia. We seek talented individuals who are passionate about pursuing ambitious cryo-EM projects on amyloids in neurodegenerative diseases.

Key Responsibilities:

  • Investigate TDP-43 and annexin A11 amyloid filament formation using cryo-EM and cryo-ET
  • Develop experimental models that recapitulate TDP-43 and annexin A11 amyloid filament formation
  • Contribute to the development of new techniques and methods for studying amyloid filaments
  • Collaborate with the wider scientific community at the LMB

Requirements:

  • PhD in a relevant field (molecular biology, structural biology, biochemistry)
  • Excellent communication and teamwork skills
  • Ability to work independently and as part of a team
  • Experience with cryo-EM and/or cryo-ET techniques

Salary and Benefits:

£39,375 per annum, plus benefits including a staff restaurant with roof terrace, on-site nursery, sports and social facilities, and a generous employee discount scheme.



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