Neurodegenerative Disease Investigator

5 days ago


Cambridgeshire and Peterborough, United Kingdom MRC Laboratory of Molecular Biology (LMB) Full time

Scientist Job Description

We are seeking two scientists to work on a project investigating TDP-43 and annexin A11 amyloid filament formation in neurodegenerative diseases at the MRC Laboratory of Molecular Biology in Cambridge, UK. This is a three-year fixed-term position suitable for candidates who have recently completed their doctoral studies or those looking to transition into a new research discipline.

The main goal of this project is to understand the molecular mechanisms underlying TDP-43 and annexin A11 amyloid filament formation and to develop experimental models that recapitulate these processes. We aim to contribute to the development of new techniques and methods for studying amyloid filaments and collaborate with the wider scientific community at the LMB.

Main Responsibilities:

  • Investigate TDP-43 and annexin A11 amyloid filament formation using cryo-EM and cryo-ET
  • Develop experimental models that recapitulate TDP-43 and annexin A11 amyloid filament formation
  • Contribute to the development of new techniques and methods for studying amyloid filaments
  • Collaborate with the wider scientific community at the LMB

Requirements:

  • PhD in a relevant field (molecular biology, structural biology, biochemistry)
  • Excellent communication and teamwork skills
  • Ability to work independently and as part of a team
  • Experience with cryo-EM and/or cryo-ET techniques

Salary:

£39,375 per annum, plus benefits including a staff restaurant with roof terrace, on-site nursery, sports and social facilities, and a generous employee discount scheme.



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