Scientist: Manufacturing Process Safety

3 hours ago

Sandwich, Kent, United Kingdom Asymchem Group Full time
Job Title: Scientist: Manufacturing Process Safety

Asymchem Group is a leading Contract Development and Manufacturing Organization (CDMO) providing drug R&D and manufacturing services to pharmaceutical and biotech companies. We are seeking a highly skilled Scientist: Manufacturing Process Safety to join our team in Sandwich, UK.

About the Role:

We are looking for a Scientist: Manufacturing Process Safety to play a pivotal role in ensuring the safety of processes intended for Manufacture of APIs, and their intermediates, on laboratory, pilot plant and commercial manufacturing scales. The successful candidate will be responsible for applying Process Safety workflows in partnership with project teams during laboratory scale-up and scale-up into pilot plant facilities, ensuring appropriate recommendations are made.

Key Responsibilities:
  • Design, execute and interpret complex laboratory experiments to accurately assess the safety of starting materials, intermediates, reagents waste streams and chemical reactions prior to scale-up and help implement suitable mitigation measures.
  • Formulate clear, concise recommendations based on process safety testing results in detailed reports and oral representation.
  • Lead / contribute to the evaluation of novel technologies and techniques to maintain world class process safety testing capabilities.
  • Maintain laboratory operations, proactively work with vendors / internal engineers to maintain equipment to a high standard and ensure optimal performance to mitigate down time.
  • Identify initiatives to enhance process safety workflows and technology to improve process safety testing efficiency.
  • Establish networks and interfaces across the pharma/CDMO space and academia.
  • Acts as a resource across the process safety network to give expert opinion and alternative insights on the interpretation of data to ensure effective assessment of chemical reaction hazards.
  • Work with external testing houses to identify and coordinate safety testing where required to generate data outside of internal capabilities and foster effective relationships.
  • Deliver process safety testing training to new starters and develop new training materials where required as the process safety function evolves.
Requirements:
  • BS/MS in chemistry or chemical engineering with a minimum 5 years (relevant API) experience in small molecule development.
  • Awareness and expertise in the various elements and concepts of process safety testing and inherently safer process design.
  • Hands-on experience operating and data interpretation from the following state of the art process safety testing equipment: Differential Scanning Calorimetry, Thermal Screening Unit (or similar), Accelerating Rate Calorimetry, Mettler Toledo RC1.
  • Experience in writing process safety testing documents to support the safe scale-up of processes during laboratory studies and tech transfer to pilot plant and commercial facilities.
  • Active participant in process hazard analyses.
  • Ability to perform complex tasks such as handling large amounts of data and performing mathematical calculations.
What We Offer:

Asymchem Group offers a competitive salary and benefits package, as well as opportunities for professional growth and development. If you are a motivated and experienced Scientist: Manufacturing Process Safety looking for a new challenge, please submit your application.

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