Process Safety Scientist

1 week ago

Sandwich, Kent, United Kingdom Asymchem Group Full time
Job Title: Process Safety Scientist

Asymchem Group is seeking a highly skilled Process Safety Scientist to join our team in the UK. This is an exciting opportunity to work with a global integrated Contract Development and Manufacturing Organization (CDMO) providing drug R&D and manufacturing for leading pharmaceutical and biotech companies.

About the Role:
  • Ensure the safety of processes intended for Manufacture of APIs, and their intermediates, on laboratory, pilot plant and commercial manufacturing scales.
  • Apply Process Safety workflows in partnership with project teams during laboratory scale-up and scale-up into pilot plant facilities, ensuring appropriate recommendations are made.
  • Design, execute and interpret complex laboratory experiments to accurately assess the safety of starting materials, intermediates, reagents waste streams and chemical reactions prior to scale-up and help implement suitable mitigation measures.
  • Formulate clear, concise recommendations based on process safety testing results in detailed reports and oral representation.
  • Lead / contribute to the evaluation of novel technologies and techniques to maintain world-class process safety testing capabilities.
  • Maintain laboratory operations, proactively work with vendors / internal engineers to maintain equipment to a high standard and ensure optimal performance to mitigate downtime.
  • Identify initiatives to enhance process safety workflows and technology to improve process safety testing efficiency.
  • Establish networks and interfaces across the pharma/CDMO space and academia.
  • Acts as a resource across the process safety network to give expert opinion and alternative insights on the interpretation of data to ensure effective assessment of chemical reaction hazards.
  • Work with external testing houses to identify and coordinate safety testing where required to generate data outside of internal capabilities and foster effective relationships.
  • Deliver process safety testing training to new starters and develop new training materials where required as the process safety function evolves.
Requirements:
  • BS/MS in chemistry or chemical engineering with a minimum 5 years (relevant API) experience in small molecule development.
  • Awareness and expertise in the various elements and concepts of process safety testing and inherently safer process design.
  • Hands-on experience operating and data interpretation from the following state-of-the-art process safety testing equipment: Differential Scanning Calorimetry, Thermal Screening Unit (or similar), Accelerating Rate Calorimetry, Mettler Toledo RC1.
  • Experience in writing process safety testing documents to support the safe scale-up of processes during laboratory studies and tech transfer to pilot plant and commercial facilities. Active participant in process hazard analyses.
  • Ability to perform complex tasks such as handling large amounts of data and performing mathematical calculations.

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